Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | SCN4A | P35499 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 2/20 | 0.40 |
| ▸ | F7 | P08709 | 1/20 | 0.40 |
| ▸ | F3 | P13726 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | NT5E | P21589 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3828474 | 1.00 | BACE1 (0.45) | BACE1EPHX2SCN4AKDM4EALDH1A1 | |
| SCHEMBL26390863 | 0.83 | KDM4E (0.45) | BACE1KDM4EALDH1A1KMT2ANT5E | |
| SCHEMBL26406670 | 0.81 | ADRB2 (0.45) | KDM4EALDH1A1KMT2ALMNANT5E | |
| SCHEMBL3822947 | 0.81 | NR4A2 (0.58) | EPHX2KDM4EALDH1A1KMT2ALMNA | |
| SCHEMBL3826784 | 0.81 | NT5E (0.54) | BACE1EPHX2SCN4AKDM4EPARP1 | |
| SCHEMBL19209591 | 0.81 | CTSD (0.41) | BACE1EPHX2SCN4AKDM4EALDH1A1 | |
| SCHEMBL11829749 | 0.79 | KDM4E (0.41) | BACE1EPHX2SCN4AKDM4EALDH1A1 | |
| SCHEMBL11133397 | 0.79 | KDM4E (0.49) | BACE1KDM4EKMT2ACTSDPARP1 | |
| SCHEMBL11831263 | 0.79 | NT5E (0.45) | BACE1EPHX2SCN4AKDM4EALDH1A1 | |
| SCHEMBL30106738 | 0.79 | NCF1 (0.55) | BACE1KDM4EALDH1A1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090566-A2 | Certain phenylacetic acids and derivatives | Novartis AG (CH) | 2009-08-19 | — | — | EP | disclosed |