Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 2/20 | 0.36 |
| ▸ | CLK1 | P49759 | 4/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.34 |
| ▸ | AKT1 | P31749 | 3/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3847500 | 0.94 | CLK1 (0.37) | FLT3SLC6A9METCLK1USP30 | |
| SCHEMBL3844926 | 0.94 | SLC6A9 (0.42) | SLC6A9METCLK1USP30 | |
| SCHEMBL3847905 | 0.93 | MET (0.35) | FLT3SLC6A9METCLK1USP30 | |
| SCHEMBL3847325 | 0.93 | SLC6A9 (0.41) | FLT3SLC6A9METCLK1USP30 | |
| SCHEMBL3850446 | 0.91 | PDE2A (0.37) | FLT3METCLK1USP30MAPK1 | |
| SCHEMBL3855253 | 0.90 | MAPK1 (0.36) | FLT3SLC6A9METCLK1USP30 | |
| SCHEMBL3850512 | 0.84 | CLK1 (0.48) | METCLK1MAPK1 | |
| SCHEMBL3847490 | 0.83 | MAPT (0.40) | FLT3METCLK1MAPK1 | |
| SCHEMBL3847097 | 0.83 | PRMT5 (0.38) | FLT3METCLK1 | |
| SCHEMBL3851316 | 0.82 | MET (0.41) | FLT3METCLK1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |