Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 6/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | CLK1 | P49759 | 6/20 | 0.34 |
| ▸ | FLT3 | P36888 | 3/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3847500 | 0.93 | CLK1 (0.37) | MAPK1SLC6A9METCLK1FLT3 | |
| SCHEMBL3847905 | 0.92 | MET (0.35) | MAPK1SLC6A9METCLK1FLT3 | |
| SCHEMBL3847325 | 0.91 | SLC6A9 (0.41) | MAPK1SLC6A9METCLK1FLT3 | |
| SCHEMBL3851179 | 0.90 | FLT3 (0.38) | MAPK1SLC6A9METCLK1FLT3 | |
| SCHEMBL3844926 | 0.89 | SLC6A9 (0.42) | SLC6A9METCLK1USP30 | |
| SCHEMBL3850446 | 0.86 | PDE2A (0.37) | MAPK1METCLK1FLT3USP30 | |
| SCHEMBL3845229 | 0.83 | SMN1; SMN2 (0.46) | METCLK1FLT3 | |
| SCHEMBL3850098 | 0.82 | EPHB3 (0.39) | METCLK1FLT3KIT | |
| Hydrochloric Acid SCHEMBL3852534 | 0.82 | FLT3 (0.41) | MAPK1FLT3HDAC3HDAC1HDAC2 | |
| SCHEMBL3848813 | 0.81 | MAPK1 (0.40) | MAPK1METCLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |