SCHEMBL3851308

SCHEMBL3851308

COc1c(C#N)sc(C)c1C1=C(c2c(C)n(C)c3ccccc23)C(F)(F)C(F)(F)C1(F)F

nearest known ligand 0.39

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ GSK3B P49841 1/20 0.35
▸ POLB P06746 2/20 0.34
▸ HIF1A Q16665 1/20 0.34
▸ LMNA P02545 2/20 0.31
▸ MAPT P10636 2/20 0.31
▸ TSHR P16473 2/20 0.31
▸ HTT P42858 2/20 0.31
▸ NPSR1 Q6W5P4 1/20 0.31
▸ EGFR P00533 1/20 0.30
▸ SRC P12931 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3854145 0.87 HIF1A (0.36) GSK3BPOLBHIF1ALMNAMAPT
SCHEMBL3848599 0.82 EGFR (0.39) GSK3BPOLBHIF1ALMNAMAPT
SCHEMBL3847894 0.77 PLA2G10 (0.36) GSK3BPOLBHIF1ALMNAMAPT
SCHEMBL28661847 0.71 GPR3 (0.39) GSK3BPOLBHIF1ALMNAMAPT
SCHEMBL3851303 0.71 POLB (0.34) GSK3BPOLBHIF1A
SCHEMBL31098897 0.69 GSK3B (0.34) GSK3BPOLBLMNAMAPTHTT
SCHEMBL16301975 0.67 GSK3B (0.38) GSK3BPOLBHIF1ALMNAMAPT
SCHEMBL9574524 0.65 GAA (0.43) GSK3BLMNAMAPTHTTNPSR1
SCHEMBL9618084 0.63 PLA2G10 (0.33) MAPT
SCHEMBL9559260 0.63 ALDH1A1 (0.38) GSK3BPOLBHIF1ALMNATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3732533-B1 SYSTEM AND METHOD FOR CUSTOMIZATION OF A PHOTOCHROMIC ARTICLE TRANSITIONS OPTICAL LTD (IE) 2025-12-10 — — EP disclosed
US-11609442-B2 System and method for customization of a photochromic article TRANSITIONS OPTICAL, LTD. (IE) 2023-03-21 — — US disclosed
US-20210055575-A1 System and Method for Customization of a Photochromic Article TRANSITIONS OPTICAL, LTD. (IE) 2021-02-25 — — US disclosed
EP-3732533-A1 SYSTEM AND METHOD FOR CUSTOMIZATION OF A PHOTOCHROMIC ARTICLE Transitions Optical, Ltd. (IE) 2020-11-04 — — EP disclosed
US-8444450-B2 Method for alternately expressing color-memorizing photochromic function in toy element, and an alternately color-memorizing photochromic toy THE PILOT INK CO., LTD. (JP) 2013-05-21 — — US disclosed
US-7575386-B2 Color-memorizing photochromic writing instrument, color-memorizing photochromic writing instrument set using the same and method for alternately expressing color-memorizing photochromic function of writing image THE PILOT INK CO., LTD. (JP) 2009-08-18 — — US disclosed
EP-1637570-B1 Color-memorizing photochromic writing instrument PILOT INK CO LTD (JP) 2007-06-27 — — EP disclosed
US-20070082977-A1 Ink composition for color-memorizing photochromic writing instrument and writing instrument using the same THE PILOT INK CO., LTD. 2007-04-12 — — US disclosed
EP-1637570-A1 Color-memorizing photochromic writing instrument THE PILOT INK CO., LTD. (JP) 2006-03-22 — — EP disclosed
US-20060053975-A1 Color-memorizing photochromic writing instrument, color-memorizing photochromic writing instrument set using the same and method for alternately expressing color-memorizing photochromic function of writing image THE PILOT INK CO., LTD. 2006-03-16 — — US disclosed
EP-1415692-B1 Method of changing color of a toy and colour changing toy PILOT INK CO LTD (JP) 2005-05-04 — — EP disclosed
US-20040135097-A1 Method for alternately expressing color-memorizing photochromic function in toy element, and an alternately color-memorizing photochromic toy THE PILOT INK CO., LTD. 2004-07-15 — — US disclosed
EP-1415692-A1 Method of changing color of a toy and colour changing toy THE PILOT INK CO., LTD. (JP) 2004-05-06 — — EP disclosed
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