Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.65 |
| ▸ | ACE | P12821 | 3/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | APAF1 | O14727 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | RECQL | P46063 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | ITGB2 | P05107 | 3/20 | 0.61 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.61 |
| ▸ | ITGAL | P20701 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | ECE1 | P42892 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MPO | P05164 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2002916 | 0.93 | BCHE (0.64) | MEN1KMT2AALOX15ACEKDM4E | |
| SCHEMBL2002917 | 0.93 | BCHE (0.64) | MEN1KMT2AALOX15ACEKDM4E | |
| SCHEMBL3848966 | 0.91 | MEN1 (0.63) | MEN1KMT2AALOX15ACEKDM4E | |
| SCHEMBL3848969 | 0.91 | MEN1 (0.63) | MEN1KMT2AALOX15ACEKDM4E | |
| Hydrochloric Acid SCHEMBL28340665 | 0.91 | BCHE (0.63) | MEN1KMT2AALOX15ACEKDM4E | |
| SCHEMBL3848569 | 0.91 | MEN1 (0.63) | MEN1KMT2AALOX15ACEKDM4E | |
| SCHEMBL6245123 | 0.90 | MEN1 (0.62) | MEN1KMT2AALOX15ACEKDM4E | |
| SCHEMBL6244061 | 0.90 | MEN1 (0.62) | MEN1KMT2AALOX15ACEKDM4E | |
| SCHEMBL8384759 | 0.90 | MEN1 (0.62) | MEN1KMT2AALOX15ACEKDM4E | |
| SCHEMBL8384762 | 0.90 | MEN1 (0.62) | MEN1KMT2AALOX15ACEKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7576222-B2 | N-{[4-(but-2-ynyloxy)phenyl]sulfonyl}-1-(2-fluorobenzyl)-5-methoxy-2-methyltryptophan; for treatment of rheumatoid arthritis, juvenile rheumatoid arthritis, ulcerative colitis, or Crohn's disease | WYETH (US) | 2009-08-18 | — | — | US | disclosed |
| US-20060160884-A1 | Alkynyl-containing tryptophan derivative inhibitors of tace/matrix metalloproteinase | WYETH (US) | 2006-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060160884-A1 | Alkynyl-containing tryptophan derivative inhibitors of tace/matrix metalloproteinase | ADAM17, TPSAB1, ADAM10 | MEN1 1856/4885KMT2A 1950/4885ALOX15 635/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.