Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.46 |
| ▸ | CSNK1A1 | P48729 | 5/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 5/20 | 0.43 |
| ▸ | GSK3B | P49841 | 4/20 | 0.43 |
| ▸ | CSNK1G2 | P78368 | 4/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2282586 | 0.78 | TAAR1 (0.59) | IKBKBMEN1KMT2ASMN1; SMN2TAAR1 | |
| SCHEMBL12235572 | 0.76 | DOT1L (0.42) | MEN1KMT2ASMN1; SMN2TAAR1DOT1L | |
| SCHEMBL578958 | 0.75 | GAA (0.54) | MEN1KMT2ASMN1; SMN2TAAR1POLB | |
| SCHEMBL10002050 | 0.75 | CSNK1A1 (0.49) | CSNK1A1CSNK1DGSK3BCSNK1G2SMN1; SMN2 | |
| SCHEMBL27825198 | 0.75 | MAPT (0.57) | ABCG2CSNK1A1CSNK1DGSK3BCSNK1G2 | |
| SCHEMBL6295526 | 0.71 | MAPT (0.51) | MEN1KMT2ASMN1; SMN2TAAR1DOT1L | |
| SCHEMBL16423097 | 0.70 | MAPK10 (0.49) | SMN1; SMN2GAAMAPT | |
| SCHEMBL2726148 | 0.69 | CA1 (0.45) | MEN1KMT2ASMN1; SMN2TAAR1DOT1L | |
| SCHEMBL384215 | 0.69 | CSNK1A1 (0.43) | ABCG2CSNK1A1CSNK1DGSK3BCSNK1G2 | |
| SCHEMBL15413751 | 0.69 | CCNB2 (0.34) | ABCG2GSK3BPOLBMAPTMAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114539163-B | HIV-1 reverse transcriptase inhibitor and its synthesis process | 复旦大学 | 2023-05-30 | — | — | CN | claimed |
| CN-114539163-A | HIV-1 reverse transcriptase inhibitor and synthetic method thereof | 复旦大学 | 2022-05-27 | — | — | CN | claimed |
| EP-4707391-A1 | NUCLEIC ACID COMPOUNDS FOR ZPI INHIBITION | e-therapeutics PLC (GB) | 2026-03-11 | — | — | EP | disclosed |
| CN-114539163-B | HIV-1 reverse transcriptase inhibitor and its synthesis process | 复旦大学 | 2023-05-30 | — | — | CN | disclosed |
| CN-114539163-A | HIV-1 reverse transcriptase inhibitor and synthetic method thereof | 复旦大学 | 2022-05-27 | — | — | CN | disclosed |
| EP-2872492-A2 | PROCESS FOR RILPIVIRINE USING NOVEL INTERMEDIATE | Hetero Research Foundation (IN) | 2015-05-20 | — | — | EP | disclosed |
| WO-2014009968-A2 | PROCESS FOR RILPIVIRINE USING NOVEL INTERMEDIATE | HETERO RESEARCH FOUNDATION (IN) | 2014-01-16 | — | — | WO | disclosed |
| EP-1888537-B1 | PROCESS FOR PREPARING 4-[(1,6-DIHYDRO-6-OXO-2-PYRIMIDINYL)AMINO BENZONITRILE | JANSSEN R & D IRELAND (IE) | 2013-09-11 | — | — | EP | disclosed |
| EP-1888537-B1 | PROCESS FOR PREPARING 4-[(1,6-DIHYDRO-6-OXO-2-PYRIMIDINYL)AMINO BENZONITRILE | JANSSEN R & D IRELAND (IE) | 2013-09-11 | — | — | EP | disclosed |
| CN-101248051-B | Process for preparing 4- [ (1, 6-dihydro-6-oxo-2-pyrimidinyl) amino ] benzonitrile | TIBOTEC PHARM LTD | 2013-07-17 | — | — | CN | disclosed |
| US-20120083606-A1 | PROCESS FOR PREPARING 4-[(1,6-DIHYDRO-6-OXO-2-PYRIMIDINYL)AMINO]BENZONITRILE | JANSSEN SCIENCES IRELAND UC (IE) | 2012-04-05 | — | — | US | disclosed |
| EP-1529032-A1 | PROCESSES FOR THE PREPARATION OF 4- 4- 4-(2 -CYANOETHENYL)-2,6-DIMETHYLPHENYL )AMINO) -2-PYRIMIDINYL)AMINO BENZONITRILE | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-05-11 | — | — | EP | disclosed |
| WO-2004050068-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING A BASIC RESPECTIVELY ACIDIC DRUG COMPOUND, A SURFACTANT AND A PHYSIOLOGICALLY TOLERABLE WATER-SOLUBLE ACID RESPECTIVELY BASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-06-17 | — | — | WO | disclosed |
| WO-2004050058-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING A BASIC RESPECTIVELY ACIDIC DRUG COMPOUND, A SURFACTANT AND A PHYSIOLOGICALLY TOLERABLE WATER-SOLUBLE ACID RESPECTIVELY BASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-06-17 | — | — | WO | disclosed |
| EP-1419152-A1 | HIV INHIBITING PYRIMIDINES DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-05-19 | — | — | EP | disclosed |
| WO-2004016581-A1 | PROCESSES FOR THE PREPARATION OF 4-[[4-[[4-(2-CYANOETHENYL)-2,6-DIMETHYLPHENYL]AMINO]-2-PYRIMIDINYL]AMINO]BENZONITRILE | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-02-26 | — | — | WO | disclosed |
| WO-2003016306-A1 | HIV INHIBITING PYRIMIDINES DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-02-27 | — | — | WO | disclosed |
| EP-1225874-A1 | ANTIVIRAL COMPOSITIONS | Janssen Pharmaceutica N.V. (BE) | 2002-07-31 | — | — | EP | disclosed |
| WO-2001022938-A1 | ANTIVIRAL COMPOSITIONS | JANSSEN PHARMACEUTICA N.V. (BE) | 2001-04-05 | — | — | WO | disclosed |
| WO-2000027825-A1 | HIV REPLICATION INHIBITING PYRIMIDINES | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120083606-A1 | PROCESS FOR PREPARING 4-[(1,6-DIHYDRO-6-OXO-2-PYRIMIDINYL)AMINO]BENZONITRILE | ME1, ALKBH1, DPYD | ABCG2 3147/4885CSNK1A1 3246/4885CSNK1D 4049/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.