Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 10/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 2/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3852193 | 0.83 | TGFBR1 (0.40) | TGFBR1CREBBPRETPDE4APDE3A | |
| SCHEMBL3849273 | 0.82 | TGFBR1 (0.40) | TGFBR1TGFBR2 | |
| SCHEMBL3852197 | 0.82 | TGFBR1 (0.40) | TGFBR1CREBBPRETMCHR1 | |
| SCHEMBL3845543 | 0.80 | TGFBR1 (0.47) | TGFBR1DYRK1A | |
| SCHEMBL3847660 | 0.79 | TGFBR1 (0.43) | TGFBR1CREBBPRETPDE4APDE3A | |
| SCHEMBL3851177 | 0.78 | TGFBR1 (0.47) | TGFBR1CREBBPRETAXLFLT3 | |
| SCHEMBL3850087 | 0.77 | TGFBR1 (0.49) | TGFBR1CREBBPRETPDE4APDE3A | |
| SCHEMBL3849190 | 0.76 | TGFBR1 (0.44) | TGFBR1CREBBPRETAXLFLT3 | |
| SCHEMBL3846789 | 0.76 | TGFBR1 (0.47) | TGFBR1CREBBPRETTGFBR2DYRK1A | |
| SCHEMBL3846702 | 0.72 | RORC (0.39) | TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |