Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LGMN | Q99538 | 1/20 | 0.44 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 13/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12836124 | 1.00 | LGMN (0.44) | LGMNTRPV4P2RX7AURKAGPR139 | |
| SCHEMBL31477305 | 0.80 | TRPV4 (0.44) | TRPV4P2RX7GPR139 | |
| SCHEMBL16449367 | 0.80 | TRPV4 (0.44) | TRPV4P2RX7GPR139 | |
| SCHEMBL15354698 | 0.80 | TRPV4 (0.44) | TRPV4P2RX7GPR139 | |
| SCHEMBL20180478 | 0.80 | TRPV4 (0.44) | TRPV4P2RX7GPR139 | |
| SCHEMBL12836123 | 0.78 | P2RX7 (0.40) | LGMNP2RX7 | |
| SCHEMBL469196 | 0.78 | TRPV4 (0.46) | TRPV4P2RX7GPR139 | |
| SCHEMBL14612275 | 0.78 | TRPV4 (0.46) | TRPV4P2RX7GPR139 | |
| SCHEMBL10115935 | 0.78 | TRPV4 (0.46) | TRPV4P2RX7GPR139 | |
| SCHEMBL4430222 | 0.78 | FFAR1 (0.44) | P2RX7CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094684-A2 | 1,5-DIPHENYL-3-BENZYLAMINO-1,5-DIHYDROPYRROLIDIN 2-ONES AS CB1 RECEPTOR MODULATORS | Eli Lilly & Company (US) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008070306-A2 | 1,5-DIPHENYL-3-BENZYLAMIN0-1,5-DIHYDR0PYRR0LIDIN-2-0NE AS CB1 RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2008-06-12 | — | — | WO | disclosed |