Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 4/20 | 0.42 |
| ▸ | CTSS | P25774 | 4/20 | 0.42 |
| ▸ | CTSB | P07858 | 3/20 | 0.42 |
| ▸ | CTSV | O60911 | 1/20 | 0.42 |
| ▸ | SUCNR1 | Q9BXA5 | 2/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | PTAFR | P25105 | 2/20 | 0.38 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL606551 | 0.77 | CTSL (0.48) | KMOCTSLCTSSCTSBCTSV | |
| SCHEMBL1399704 | 0.73 | KMO (0.67) | KMOSUCNR1CDK4CCND1EGFR | |
| SCHEMBL606550 | 0.71 | CTSL (0.46) | KMOCTSLCTSSCTSBCTSV | |
| SCHEMBL14507768 | 0.69 | MKNK1 (0.72) | KMOCDK4CCND1EGFR | |
| SCHEMBL13626336 | 0.68 | KMO (0.61) | KMOCTSLCTSSCTSBCTSV | |
| SCHEMBL3174593 | 0.68 | PSMB5 (0.57) | KMOCTSLCTSSCTSBCTSV | |
| Hydrochloric Acid SCHEMBL1326503 | 0.67 | PSMB5 (0.56) | CTSLCTSSCTSBCTSVCTSK | |
| SCHEMBL13188259 | 0.67 | KMO (0.69) | KMOCDK4CCND1 | |
| SCHEMBL12191038 | 0.67 | XDH (0.49) | KMOCTSLCTSSCTSBCTSV | |
| SCHEMBL607084 | 0.67 | NPC1 (0.53) | CTSLCTSSCTSBCTSVLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7576206-B2 | Proteasome inhibitors and methods of using the same | CEPHALON, INC. (US) | 2009-08-18 | — | — | US | disclosed |