SCHEMBL3855184

SCHEMBL3855184

COc1ccc(C=CC=Cc2ccc3sc(C)c(C4=C(c5c(C)sc6ccc(C=CC=Cc7ccc(OC)cc7)cc56)C(F)(F)C(F)(F)C4(F)F)c3c2)cc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ RELA Q04206 5/20 0.36
▸ LMNA P02545 1/20 0.36
▸ TP53 P04637 1/20 0.36
▸ CYP3A4 P08684 1/20 0.36
▸ TSHR P16473 1/20 0.36
▸ KDM4E B2RXH2 1/20 0.36
▸ ALDH1A1 P00352 1/20 0.36
▸ NFE2L2 Q16236 3/20 0.36
▸ TUBB1 Q9H4B7 3/20 0.35
▸ AHR P35869 2/20 0.35
▸ TUBB4A P04350 2/20 0.35
▸ TUBB P07437 2/20 0.35
▸ TUBA3C P0DPH7 2/20 0.35
▸ TUBA1B P68363 2/20 0.35
▸ TUBA4A P68366 2/20 0.35
▸ TUBB4B P68371 2/20 0.35
▸ TUBB3 Q13509 2/20 0.35
▸ TUBB2A Q13885 2/20 0.35
▸ TUBB8 Q3ZCM7 2/20 0.35
▸ TUBA3E Q6PEY2 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3855910 0.95 RELA (0.41) RELALMNATP53CYP3A4TSHR
SCHEMBL3853710 0.93 TUBB1 (0.33) RELALMNATP53CYP3A4TSHR
SCHEMBL3853935 0.92 TUBB1 (0.35) RELANFE2L2TUBB1AHRTUBB4A
SCHEMBL3855182 0.91 RELA (0.36) RELALMNATP53CYP3A4TSHR
SCHEMBL3871298 0.88 TUBB1 (0.37) RELANFE2L2TUBB1AHRTUBB4A
SCHEMBL3849455 0.87 INSR (0.39) TUBB1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL9226869 0.86 HDAC8 (0.36) TUBB1HDAC8HDAC6ALOX5
SCHEMBL3855911 0.86 RELA (0.41) RELALMNATP53CYP3A4TSHR
SCHEMBL3853705 0.84 TUBB1 (0.33) RELALMNATP53CYP3A4TSHR
SCHEMBL5090816 0.84 L3MBTL1 (0.41) TSHRKDM4EALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3732533-B1 SYSTEM AND METHOD FOR CUSTOMIZATION OF A PHOTOCHROMIC ARTICLE TRANSITIONS OPTICAL LTD (IE) 2025-12-10 — — EP disclosed
US-11609442-B2 System and method for customization of a photochromic article TRANSITIONS OPTICAL, LTD. (IE) 2023-03-21 — — US disclosed
US-20210055575-A1 System and Method for Customization of a Photochromic Article TRANSITIONS OPTICAL, LTD. (IE) 2021-02-25 — — US disclosed
EP-3732533-A1 SYSTEM AND METHOD FOR CUSTOMIZATION OF A PHOTOCHROMIC ARTICLE Transitions Optical, Ltd. (IE) 2020-11-04 — — EP disclosed
US-8444450-B2 Method for alternately expressing color-memorizing photochromic function in toy element, and an alternately color-memorizing photochromic toy THE PILOT INK CO., LTD. (JP) 2013-05-21 — — US disclosed
US-7575386-B2 Color-memorizing photochromic writing instrument, color-memorizing photochromic writing instrument set using the same and method for alternately expressing color-memorizing photochromic function of writing image THE PILOT INK CO., LTD. (JP) 2009-08-18 — — US disclosed
EP-1637570-B1 Color-memorizing photochromic writing instrument PILOT INK CO LTD (JP) 2007-06-27 — — EP disclosed
US-20070082977-A1 Ink composition for color-memorizing photochromic writing instrument and writing instrument using the same THE PILOT INK CO., LTD. 2007-04-12 — — US disclosed
EP-1637570-A1 Color-memorizing photochromic writing instrument THE PILOT INK CO., LTD. (JP) 2006-03-22 — — EP disclosed
US-20060053975-A1 Color-memorizing photochromic writing instrument, color-memorizing photochromic writing instrument set using the same and method for alternately expressing color-memorizing photochromic function of writing image THE PILOT INK CO., LTD. 2006-03-16 — — US disclosed
EP-1415692-B1 Method of changing color of a toy and colour changing toy PILOT INK CO LTD (JP) 2005-05-04 — — EP disclosed
EP-1415692-A1 Method of changing color of a toy and colour changing toy THE PILOT INK CO., LTD. (JP) 2004-05-06 — — EP disclosed
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