Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.33 |
| ▸ | VDR | P11473 | 3/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 3/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | F2 | P00734 | 1/20 | 0.30 |
| ▸ | F10 | P00742 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3855863 | 0.92 | SRD5A2 (0.39) | TP53ALDH1A1KDM4EHDAC6SRD5A2 | |
| SCHEMBL3850271 | 0.91 | VDR (0.39) | TP53POLBTHRBMAPK1SMN1; SMN2 | |
| SCHEMBL3851229 | 0.90 | TP53 (0.35) | TP53POLBTHRBMAPK1SMN1; SMN2 | |
| SCHEMBL5971306 | 0.88 | MAPK1 (0.35) | TP53POLBTHRBMAPK1SMN1; SMN2 | |
| SCHEMBL3859965 | 0.82 | VDR (0.40) | TP53VDRAR | |
| SCHEMBL3851369 | 0.82 | TBXAS1 (0.34) | TP53SMN1; SMN2ALDH1A1KDM4EHDAC6 | |
| SCHEMBL3855825 | 0.81 | MAPK1 (0.36) | TP53POLBTHRBMAPK1SMN1; SMN2 | |
| SCHEMBL5970911 | 0.80 | SMN1; SMN2 (0.34) | TP53POLBTHRBMAPK1SMN1; SMN2 | |
| SCHEMBL5971590 | 0.79 | VDR (0.41) | TP53POLBTHRBMAPK1SMN1; SMN2 | |
| SCHEMBL5971554 | 0.79 | SRD5A2 (0.36) | ALDH1A1KDM4EHDAC6SRD5A2VDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7579488-B2 | Vitamin D receptor modulators | ELI LILLY AND COMPANY (US) | 2009-08-25 | — | — | US | disclosed |
| US-20070106095-A1 | Vitamin d receptor modulators | ELI LILLY AND COMPANY | 2007-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070106095-A1 | Vitamin d receptor modulators | VDR, CYP2R1, CYP24A1 | TP53 2858/4885POLB 4532/4885THRB 648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.