Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGXT | P21549 | 1/20 | 0.43 |
| ▸ | ICMT | O60725 | 2/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | QPCT | Q16769 | 2/20 | 0.39 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.39 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27731268 | 0.91 | ICMT (0.52) | ICMTCFTRCXCR2PTGS2SERPINE1 | |
| SCHEMBL27751731 | 0.90 | KIF11 (0.42) | AGXTICMTKIF11CFTRCXCR2 | |
| SCHEMBL27731265 | 0.87 | SERPINE1 (0.43) | ICMTHTR6SERPINE1 | |
| SCHEMBL27751974 | 0.84 | SERPINE1 (0.55) | ICMTSERPINE1BACE1 | |
| SCHEMBL5138333 | 0.81 | HTR6 (0.45) | CFTRPTGS2HTR6LMNAMAPT | |
| SCHEMBL27731250 | 0.80 | ICMT (0.51) | ICMTHTR6LMNAGRIN1GRIN2B | |
| SCHEMBL27751725 | 0.79 | HDAC8 (0.40) | ICMTSERPINE1LMNAMAPT | |
| SCHEMBL27731261 | 0.78 | ICMT (0.44) | ICMTHTR6QPCTQPCTLSERPINE1 | |
| SCHEMBL27751707 | 0.78 | MAPT (0.45) | ICMTSERPINE1LMNAMAPT | |
| SCHEMBL27731267 | 0.77 | TLR8 (0.45) | AGXTICMTKIF11GRIN2BSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010171-A2 | INHIBITORS OF PAI-1 FOR TREATMENT OF MUSCULAR CONDITIONS | Wyeth a Corporation of the State of Delaware (US) | 2009-01-07 | — | — | EP | claimed |
| WO-2007098278-A2 | INHIBITORS OF PAI-1 FOR TREATMENT OF MUSCULAR CONDITIONS | WYETH (US) | 2007-08-30 | — | — | WO | claimed |
| CN-101384256-A | PAI-1 Inhibitors for the Treatment of Muscle Conditions | WYETH CORP (US) | 2009-03-11 | — | — | CN | disclosed |