Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 6/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.38 |
| ▸ | PRKCI | P41743 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | CBFB | Q13951 | 1/20 | 0.38 |
| ▸ | SQOR | Q9Y6N5 | 2/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.36 |
| ▸ | ABL2 | P42684 | 1/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | CLK3 | P49761 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3850901 | 0.85 | DYRK1A (0.41) | TGFBR1MAPK14PIK3CAMETAP2METAP1 | |
| Hydrochloric Acid SCHEMBL3853873 | 0.84 | DYRK1A (0.40) | TGFBR1MAPK14PIK3CAMETAP2METAP1 | |
| SCHEMBL7856946 | 0.83 | TGFBR1 (0.51) | TGFBR1MAPK14METAP1SQOR | |
| Hydrochloric Acid SCHEMBL3846888 | 0.81 | ACVR1 (0.41) | TGFBR1MAPK14PIK3CAACVR1PRKCI | |
| SCHEMBL5139747 | 0.81 | TGFBR1 (0.40) | TGFBR1MAPK14PIK3CAACVR1DYRK1B | |
| SCHEMBL3859370 | 0.80 | ACVR1 (0.44) | MAPK14PIK3CAALOX5ACVR1 | |
| Gw680975X SCHEMBL373303 | 0.80 | TGFBR1 (0.59) | TGFBR1MAPK14SQOR | |
| SCHEMBL5490810 | 0.79 | TGFBR1 (0.54) | TGFBR1MAPK14METAP1SQOR | |
| SCHEMBL3852041 | 0.78 | TDO2 (0.49) | MAPK14PIK3CADYRK1A | |
| SCHEMBL14519488 | 0.78 | MAPK14 (0.55) | TGFBR1MAPK14ALOX5ACVR1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |