SCHEMBL5139747

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL5138195	0.85	MAP4K4 (0.52)	TGFBR1
	SCHEMBL5138443	0.82	TGFBR1 (0.46)	TGFBR1MAPK14PIK3CAPIK3CDPIK3CG
	SCHEMBL3858025	0.81	TGFBR1 (0.43)	TGFBR1MAPK14DYRK1BACVR1PIK3CA
	SCHEMBL5138250	0.80	NPC1 (0.51)	TGFBR1MAPK14KDRCLK2CLK3
	SCHEMBL5139684	0.79	ACVR1 (0.57)	TGFBR1ACVR1PIK3CDPIM1
	SCHEMBL5139502	0.78	MAP4K4 (0.42)	TGFBR1DYRK1A
	SCHEMBL3850901	0.78	DYRK1A (0.41)	TGFBR1MAPK14PIK3CAPIK3CDPIK3CG
	SCHEMBL27628470	0.78	CHEK2 (0.41)	TGFBR1DYRK1ATGFBR2
	Hydrochloric Acid SCHEMBL3853873	0.77	DYRK1A (0.40)	TGFBR1MAPK14PIK3CAPIK3CDPIK3CG
	SCHEMBL5200922	0.77	TDO2 (0.47)	TGFBR1MAPK14PIK3CAPIK3CDPIK3CG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.