Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 8/20 | 0.37 |
| ▸ | CTSK | P43235 | 6/20 | 0.37 |
| ▸ | CTSB | P07858 | 4/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 3/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL612632 | 0.86 | DDB1 (0.43) | IDO1NQO2CTSSCTSKMALT1 | |
| SCHEMBL238012 | 0.83 | PTGES (0.43) | IDO1CTSSCTSKCTSBMALT1 | |
| SCHEMBL613498 | 0.83 | TDP1 (0.45) | IDO1NQO2CTSSCTSKMALT1 | |
| SCHEMBL614479 | 0.82 | CTSK (0.47) | IDO1NQO2CTSSCTSKCTSB | |
| SCHEMBL10318009 | 0.81 | KDM4E (0.46) | IDO1NQO2MALT1MEN1GAA | |
| SCHEMBL235309 | 0.80 | DDB1 (0.41) | NQO2CTSSCTSKMALT1MEN1 | |
| SCHEMBL613522 | 0.80 | NQO2 (0.43) | IDO1NQO2CTSSCTSKMALT1 | |
| SCHEMBL17735443 | 0.79 | POLB (0.45) | IDO1NQO2CTSSCTSKMALT1 | |
| SCHEMBL16079975 | 0.79 | POLB (0.45) | IDO1NQO2CTSSCTSKMALT1 | |
| SCHEMBL16031480 | 0.79 | NQO2 (0.51) | IDO1NQO2CTSSCTSKMALT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076122-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2009005794-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-01-08 | — | — | WO | disclosed |