Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 6/20 | 0.47 |
| ▸ | CTSS | P25774 | 5/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 2/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL613498 | 0.89 | TDP1 (0.45) | CTSKCTSSIDO1SIGMAR1MMP1 | |
| SCHEMBL613522 | 0.88 | NQO2 (0.43) | CTSKCTSSIDO1SIGMAR1NQO2 | |
| SCHEMBL1710761 | 0.87 | IDO1 (0.47) | CTSKCTSSIDO1SIGMAR1MMP1 | |
| SCHEMBL13959625 | 0.87 | NR1H2 (0.40) | CTSKCTSSIDO1SIGMAR1MMP1 | |
| SCHEMBL16084764 | 0.86 | RIPK1 (0.53) | CTSKCTSSIDO1SYKMEN1 | |
| SCHEMBL1521024 | 0.86 | RIPK1 (0.53) | CTSKCTSSIDO1SYKMEN1 | |
| SCHEMBL613231 | 0.85 | MAPT (0.41) | CTSKIDO1SIGMAR1MMP1MMP3 | |
| SCHEMBL611408 | 0.85 | CTSK (0.40) | CTSKCTSSIDO1SIGMAR1MMP1 | |
| SCHEMBL16031455 | 0.84 | KMT2A (0.48) | IDO1SYKMEN1KMT2A | |
| SCHEMBL16031452 | 0.84 | KMT2A (0.48) | IDO1SYKMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8716529-B2 | Amine derivative compounds for treating ophthalmic diseases and disorders | ACUCELA INC. (US) | 2014-05-06 | — | — | US | disclosed |
| CN-101917980-B | Amine derivative compounds for the treatment of ophthalmic diseases and disorders | ACUCELA INC | 2013-12-11 | — | — | CN | disclosed |
| US-20120041039-A1 | AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA INC. (US) | 2012-02-16 | — | — | US | disclosed |
| CN-101917980-A | Amine derivative compounds for the treatment of ophthalmic diseases and disorders | ACUCELA INC | 2010-12-15 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120041039-A1 | AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | PDE6D, CLN6, AADAT | CTSK 3267/4885CTSS 3746/4885IDO1 505/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.