Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 6/20 | 0.42 |
| ▸ | CES2 | O00748 | 3/20 | 0.41 |
| ▸ | CES1 | P23141 | 3/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.36 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | ALB | P02768 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18742412 | 0.92 | HDAC4 (0.47) | HDAC4CES2CES1OPRL1BCHE | |
| SCHEMBL10528639 | 0.87 | HDAC4 (0.59) | HDAC4OPRL1LMNA | |
| SCHEMBL9314481 | 0.81 | AKR1C1 (0.45) | HDAC4CES2CES1ALB | |
| SCHEMBL4744830 | 0.80 | HDAC4 (0.57) | HDAC4OPRL1ELOVL1LMNAHDAC3 | |
| SCHEMBL20954810 | 0.77 | TSHR (0.55) | OPRL1 | |
| SCHEMBL18742673 | 0.76 | HDAC4 (0.62) | HDAC4CES2CES1OPRL1BCHE | |
| SCHEMBL23660729 | 0.75 | TSHR (0.47) | OPRL1HDAC1HDAC2 | |
| SCHEMBL10002458 | 0.75 | HDAC4 (0.60) | HDAC4OPRL1ELOVL1LMNA | |
| SCHEMBL43075 | 0.75 | HDAC4 (0.65) | HDAC4OPRL1ELOVL1LMNA | |
| SCHEMBL19814324 | 0.74 | MAPT (0.39) | HDAC4OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1877377-A2 | PROCESS FOR PREPARING 3,3-DISUBSTITUTED OXINDOLES AND THIO-OXINDOLES | Wyeth (US) | 2008-01-16 | — | — | EP | claimed |
| WO-2006118955-A2 | PROCESS FOR PREPARING 3,3-DISUBSTITUTED OXINDOLES AND THIO-OXINDOLES | WYETH (US) | 2006-11-09 | — | — | WO | claimed |
| US-20060247441-A1 | Process for preparing 3,3-disubstituted oxindoles and thio-oxindoles | WYETH (US) | 2006-11-02 | — | — | US | claimed |
| US-7595338-B2 | Process for preparing 3,3-disubstituted oxindoles and thio-oxindoles | WYETH (US) | 2009-09-29 | — | — | US | disclosed |
| US-7595338-B2 | Process for preparing 3,3-disubstituted oxindoles and thio-oxindoles | WYETH (US) | 2009-09-29 | — | — | US | disclosed |
| US-20080319204-A1 | PROCESS FOR THE SYNTHESIS OF PROGESTERONE RECEPTOR MODULATORS | WYETH (US) | 2008-12-25 | — | — | US | disclosed |
| US-20080319204-A1 | PROCESS FOR THE SYNTHESIS OF PROGESTERONE RECEPTOR MODULATORS | WYETH (US) | 2008-12-25 | — | — | US | disclosed |
| EP-1877377-A2 | PROCESS FOR PREPARING 3,3-DISUBSTITUTED OXINDOLES AND THIO-OXINDOLES | Wyeth (US) | 2008-01-16 | — | — | EP | disclosed |
| WO-2006118955-A2 | PROCESS FOR PREPARING 3,3-DISUBSTITUTED OXINDOLES AND THIO-OXINDOLES | WYETH (US) | 2006-11-09 | — | — | WO | disclosed |
| US-20060247441-A1 | Process for preparing 3,3-disubstituted oxindoles and thio-oxindoles | WYETH (US) | 2006-11-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080319204-A1 | PROCESS FOR THE SYNTHESIS OF PROGESTERONE RECEPTOR MODULATORS | OXTR, PGR, NR3C2 | HDAC4 1237/4885CES2 1160/4885CES1 2170/4885 |
| US-20060247441-A1 | Process for preparing 3,3-disubstituted oxindoles and thio-oxindoles | TPMT, TH, HTR3C | HDAC4 3395/4885CES2 2736/4885CES1 3625/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.