Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.48 |
| ▸ | KIF11 | P52732 | 1/20 | 0.47 |
| ▸ | TOP1 | P11387 | 2/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29030628 | 0.86 | ALDH1A1 (0.61) | ALDH1A1KDM4ECTDSP1TGFBR1MEN1 | |
| SCHEMBL30566980 | 0.86 | ALDH1A1 (0.61) | ALDH1A1KDM4ECTDSP1TGFBR1MEN1 | |
| SCHEMBL386268 | 0.84 | KDM4E (0.51) | ALDH1A1KDM4ECTDSP1TOP1TGFBR1 | |
| SCHEMBL386262 | 0.79 | ESR1 (0.36) | KIF11 | |
| Hydrochloric Acid SCHEMBL386200 | 0.74 | KDM4E (0.41) | ALDH1A1KDM4ECTDSP1TOP1 | |
| SCHEMBL385322 | 0.74 | ALDH1A1 (0.47) | ALDH1A1KDM4ECTDSP1POLBMAPT | |
| SCHEMBL4151828 | 0.73 | KIF11 (0.63) | ALDH1A1KIF11BACE1SCN2AGLO1 | |
| SCHEMBL385488 | 0.69 | KDM4E (0.43) | ALDH1A1KDM4ECTDSP1BACE1POLB | |
| SCHEMBL386389 | 0.69 | FYN (0.53) | ALDH1A1KDM4ECTDSP1POLBMAPT | |
| SCHEMBL385326 | 0.69 | ALDH1A1 (0.44) | ALDH1A1KDM4ECTDSP1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101625-B2 | Pyrimidinones as Casein Kinase II (CK2) modulators | EXELIXIS, INC. (US) | 2012-01-24 | — | — | US | disclosed |
| US-20090215803-A1 | Pyrimidinones as Casein Kinase II (CK2) Modulators | EXELIXIS, INC. | 2009-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215803-A1 | Pyrimidinones as Casein Kinase II (CK2) Modulators | CSNK2A1, CSNK1A1, CSNK2A2 | ALDH1A1 3986/4885KDM4E 1821/4885CTDSP1 376/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.