Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | BACE1 | P56817 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12204779 | 0.88 | ALDH1A1 (0.61) | ALDH1A1KDM4EMEN1PKMKMT2A | |
| SCHEMBL14799311 | 0.81 | HTR1A (0.46) | ALDH1A1KDM4EMEN1KMT2ABACE1 | |
| SCHEMBL2474305 | 0.80 | ALDH1A1 (0.88) | ALDH1A1KDM4EMEN1KMT2ALMNA | |
| SCHEMBL3975714 | 0.80 | ALDH1A1 (0.59) | ALDH1A1KDM4EMEN1KMT2ABACE1 | |
| SCHEMBL2469303 | 0.80 | ALDH1A1 (0.63) | ALDH1A1KDM4EMEN1KMT2ADRD2 | |
| SCHEMBL6867851 | 0.79 | ALDH1A1 (0.43) | ALDH1A1KDM4EMEN1PKMKMT2A | |
| SCHEMBL6867856 | 0.79 | ALDH1A1 (0.43) | ALDH1A1KDM4EMEN1PKMKMT2A | |
| Hydrochloric Acid SCHEMBL18863751 | 0.79 | ALDH1A1 (0.57) | ALDH1A1KDM4EMEN1KMT2ABACE1 | |
| SCHEMBL9814011 | 0.77 | MEN1 (0.46) | ALDH1A1KDM4EMEN1PKMKMT2A | |
| SCHEMBL9808263 | 0.75 | L3MBTL1 (0.68) | ALDH1A1MEN1PKMKMT2ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220401391-A1 | METHODS AND COMPOSITIONS FOR TREATING PAIN | APKARIAN TECHNOLOGIES LLC | 2022-12-22 | — | — | US | disclosed |
| US-11419857-B2 | Methods and compositions for treating pain | APKARIAN TECHNOLOGIES LLC (US) | 2022-08-23 | — | — | US | disclosed |
| EP-3946302-A1 | METHODS AND COMPOSITIONS FOR TREATING PAIN | Apkarian Technologies LLC (US) | 2022-02-09 | — | — | EP | disclosed |
| WO-2020227646-A1 | METHODS AND COMPOSITIONS FOR TREATING PAIN | APKARIAN TECHNOLOGIES LLC (US) | 2020-11-12 | — | — | WO | disclosed |
| US-20200046687-A1 | METHODS AND COMPOSITIONS FOR TREATING PAIN | APKARIAN TECHNOLOGIES LLC | 2020-02-13 | — | — | US | disclosed |
| US-20170143681-A1 | METHODS AND COMPOSITIONS FOR TREATING PAIN | APKARIAN TECHNOLOGIES LLC | 2017-05-25 | — | — | US | disclosed |
| US-8703764-B2 | Combination therapy for dementia, depression and apathy | SHELDON LESLIE JAMES (CA) | 2014-04-22 | — | — | US | disclosed |
| EP-1713486-A4 | COMBINATION THERAPY FOR DEMENTIA,DEPRESSION AND APATHY | SHELDON LESLIE JAMES (CA) | 2009-04-29 | — | — | EP | disclosed |
| US-20060287299-A1 | Combination therapy for dementia, depression and apathy | SHELDON LESLIE J | 2006-12-21 | — | — | US | disclosed |
| EP-1713486-A1 | COMBINATION THERAPY FOR DEMENTIA,DEPRESSION AND APATHY | Sheldon, Leslie James (CA) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005053703-A1 | COMBINATION THERAPY FOR DEMENTIA, DEPRESSION AND APATHY | SHELDON LESLIE JAMES (CA) | 2005-06-16 | — | — | WO | disclosed |