Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA4 | P22748 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 5/20 | 0.42 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperidine SCHEMBL11861125 | 0.88 | KDM4E (0.42) | ALDH1A1TDP1MAPK1CA1CA2 | |
| SCHEMBL11215650 | 0.85 | ALDH1A1 (0.50) | ALDH1A1TDP1MAPK1CA1CA2 | |
| SCHEMBL528982 | 0.84 | TSHR (0.51) | ALDH1A1CA1CA2KDM4ETSHR | |
| SCHEMBL11696154 | 0.84 | NPC1 (0.50) | TDP1CA1CA2KDM4EMAPT | |
| SCHEMBL11692745 | 0.83 | ALDH1A1 (0.55) | ALDH1A1TDP1MAPK1CA1CA2 | |
| SCHEMBL28071044 | 0.82 | ALDH1A1 (0.49) | ALDH1A1TDP1MAPK1CA1CA2 | |
| SCHEMBL11841323 | 0.80 | HDAC8 (0.42) | GAATSHRMEN1KMT2A | |
| SCHEMBL11696436 | 0.80 | ATM (0.55) | ALDH1A1TDP1MAPTPOLBGAA | |
| SCHEMBL11693909 | 0.80 | KDM4E (0.46) | ALDH1A1TDP1MAPK1CA1CA2 | |
| SCHEMBL16258585 | 0.79 | ALDH1A1 (0.57) | ALDH1A1TDP1MAPK1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240208992-A1 | MACROCYCLES AS CFTR MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2024-06-27 | — | — | US | disclosed |
| US-20230391763-A1 | MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY | EVOTEC INTERNATIONAL GMBH (DE) | 2023-12-07 | — | — | US | disclosed |
| CN-106132954-B | 1,3- benzodioxole derivative | 第三共株式会社 | 2019-01-08 | — | — | CN | disclosed |
| CN-106132954-A | 1,3 benzodioxole derivant | 第三共株式会社 | 2016-11-16 | — | — | CN | disclosed |
| CN-105408321-A | Novel derivatives of indole and pyrrole, method for the production thereof and pharmaceutical compositions containing same | SERVIER LAB | 2016-03-16 | — | — | CN | disclosed |
| CN-101910168-A | Tropane compounds | EXELIXIS INC | 2010-12-08 | — | — | CN | disclosed |
| US-7524976-B2 | Process for preparing difluorobenzo-1,3-dioxole-5-carboxylic acid derivatives | LANXESS DEUTSCHLAND GMBH (DE) | 2009-04-28 | — | — | US | disclosed |
| EP-1595876-B1 | Process for the preparation of derivatives of difluorobenzo-(1,3)-dioxole-5-carboxylic acid | SALTIGO GMBH (DE) | 2007-12-12 | — | — | EP | disclosed |
| US-20050277692-A1 | Process for preparing difluorobenzo-1,3-dioxole-5-carboxylic acid derivatives | LANXESS DEUTSCHLAND GMBH (DE) | 2005-12-15 | — | — | US | disclosed |
| EP-1595876-A1 | Process for the preparation of derivatives of difluorobenzo-(1,3)-dioxole-5-carboxylic acid | Lanxess Deutschland GmbH (DE) | 2005-11-16 | — | — | EP | disclosed |
| WO-2001028981-A1 | 1-CYCLOHEXENE-1-CARBOXYLIC ACID AND 1-CYCLOHEXENE-1-CARBOXYLATES AS NEURAMINIDASE INHIBITORS | ABBOTT LABORATORIES (US) | 2001-04-26 | — | — | WO | disclosed |
| WO-1997000872-A1 | 1,3,8-TRIAZA- AND 3,8-DIAZA-1-OXASPIRO(4,5)DECANE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 1997-01-09 | — | — | WO | disclosed |
| US-4389403-A | HYPOTENSIVE AGENTS | BASF AKTIENGESELLSCHAFT (DE) | 1983-06-21 | — | — | US | disclosed |
| EP-0037471-A1 | 1-Aroyl-2-phenylamino-2-imidazolines, their preparation and their pharmaceutical compositions | BASF Aktiengesellschaft (DE) | 1981-10-14 | — | — | EP | disclosed |
| US-4058607-A | DIHALOVINYL DIALKYL PHOSPHATE, 1,3-BENZODIOXOLES | AIRWICK INDUSTRIES, INC. (US) | 1977-11-15 | — | — | US | disclosed |
| US-3962415-A | Insecticide evaporator comprising DDVP with synergized benzodioxole compound as stabilizer | AIRWICK INDUSTRIES, INC. (US) | 1976-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230391763-A1 | MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY | CRH, AVPR1B, CRHR2 | ALDH1A1 3614/4885TDP1 1775/4885MAPK1 773/4885 |
| US-20240208992-A1 | MACROCYCLES AS CFTR MODULATORS | CFTR, PKD1, ARRB1 | ALDH1A1 2257/4885TDP1 4270/4885MAPK1 2666/4885 |
| US-20050277692-A1 | Process for preparing difluorobenzo-1,3-dioxole-5-carboxylic acid derivatives | BROX, DDT, DAO | ALDH1A1 351/4885TDP1 1958/4885MAPK1 1432/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.