Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.44 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1548860 | 0.80 | MAPT (0.53) | KDM4ERAB9APSMD14MAPTSMN1; SMN2 | |
| SCHEMBL5296175 | 0.71 | MTNR1A (0.52) | ALOX5MTNR1AMTNR1BKDM4EMAPT | |
| SCHEMBL5308272 | 0.70 | TSHR (0.51) | MTNR1AMTNR1BKDM4ERAB9AMAPT | |
| SCHEMBL1072870 | 0.69 | CFTR (0.54) | RAB9AMAPTSMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL1073197 | 0.69 | CYP1A2 (0.50) | KDM4ERAB9APSMD14MAPTSMN1; SMN2 | |
| SCHEMBL18229465 | 0.68 | OXER1 (0.64) | MTNR1AMTNR1BKDM4EMAPTALDH1A1 | |
| SCHEMBL13938710 | 0.68 | IMPDH2 (0.46) | KDM4EIMPDH2ALDH1A1GAANPC1 | |
| SCHEMBL1021903 | 0.67 | SMN1; SMN2 (0.65) | MAPTSMN1; SMN2TP53POLBLMNA | |
| SCHEMBL14574432 | 0.67 | CYP2D6 (0.51) | KDM4ERAB9ASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL6014774 | 0.67 | KDM4E (0.61) | MTNR1AMTNR1BKDM4ERAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954274-A4 | SUBSTITUTED QUINOLONES AND METHODS OF USE | CHEMOCENTRYX INC (US) | 2009-01-07 | — | — | EP | disclosed |
| EP-1954274-A2 | SUBSTITUTED QUINOLONES AND METHODS OF USE | ChemoCentryx Inc (US) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007059108-A2 | SUBSTITUTED QUINOLONES AND METHODS OF USE | CHEMOCENTRYX, INC. (US) | 2007-05-24 | — | — | WO | disclosed |