Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.40 |
| ▸ | WNT3A | P56704 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA3 | P07451 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.40 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.40 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31726105 | 0.81 | IDO1 (0.43) | ALDH1A1CTNNB1WNT3AMRGPRX4KDM4E | |
| SCHEMBL20638691 | 0.80 | ALDH1A1 (0.43) | ALDH1A1TSHRTP53CASP1SMN1; SMN2 | |
| SCHEMBL31697194 | 0.78 | SMN1; SMN2 (0.54) | TSHRSMN1; SMN2CNR1CTNNB1WNT3A | |
| SCHEMBL3863958 | 0.78 | SMN1; SMN2 (0.54) | TSHRSMN1; SMN2CNR1CTNNB1WNT3A | |
| SCHEMBL29397048 | 0.78 | CTNNB1 (0.43) | ALDH1A1CNR1CTNNB1WNT3AMRGPRX4 | |
| SCHEMBL25028468 | 0.78 | CTNNB1 (0.43) | ALDH1A1CNR1CTNNB1WNT3AMRGPRX4 | |
| SCHEMBL8759431 | 0.77 | ALPL (0.48) | TSHRCTNNB1WNT3ANPC1RAB9A | |
| SCHEMBL5278435 | 0.74 | CTNNB1 (0.37) | CTNNB1WNT3AMRGPRX4KDM4EHDAC4 | |
| SCHEMBL4472381 | 0.73 | ALDH1A1 (0.48) | ALDH1A1TSHRTP53CASP1SMN1; SMN2 | |
| SCHEMBL31726102 | 0.73 | DTYMK (0.44) | ALDH1A1TSHRCTNNB1WNT3ACA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1595876-B1 | Process for the preparation of derivatives of difluorobenzo-(1,3)-dioxole-5-carboxylic acid | SALTIGO GMBH (DE) | 2007-12-12 | — | — | EP | claimed |
| US-12281057-B2 | Carboxamides as modulators of sodium channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2025-04-22 | — | — | US | disclosed |
| EP-3651752-B1 | CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2024-11-20 | — | — | EP | disclosed |
| US-20230286907-A1 | CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-09-14 | — | — | US | disclosed |
| US-20230286907-A1 | CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-09-14 | — | — | US | disclosed |
| US-20230286907-A1 | CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-09-14 | — | — | US | disclosed |
| US-11603351-B2 | Carboxamides as modulators of sodium channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-03-14 | — | — | US | disclosed |
| US-20210094906-A1 | CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED | 2021-04-01 | — | — | US | disclosed |
| US-20210094906-A1 | CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED | 2021-04-01 | — | — | US | disclosed |
| EP-3651752-A1 | CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2020-05-20 | — | — | EP | disclosed |
| US-10647661-B2 | Carboxamides as modulators of sodium channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2020-05-12 | — | — | US | disclosed |
| CN-111065383-A | Carboxamides useful as sodium channel modulators | 沃泰克斯药物股份有限公司 | 2020-04-24 | — | — | CN | disclosed |
| US-20190016671-A1 | CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS (EUROPE) LIMITED (GB) | 2019-01-17 | — | — | US | disclosed |
| US-20190016671-A1 | CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS (EUROPE) LIMITED (GB) | 2019-01-17 | — | — | US | disclosed |
| WO-2019014352-A1 | CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2019-01-17 | — | — | WO | disclosed |
| WO-2019014352-A1 | CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2019-01-17 | — | — | WO | disclosed |
| US-7524976-B2 | Process for preparing difluorobenzo-1,3-dioxole-5-carboxylic acid derivatives | LANXESS DEUTSCHLAND GMBH (DE) | 2009-04-28 | — | — | US | disclosed |
| EP-1595876-B1 | Process for the preparation of derivatives of difluorobenzo-(1,3)-dioxole-5-carboxylic acid | SALTIGO GMBH (DE) | 2007-12-12 | — | — | EP | disclosed |
| US-20050277692-A1 | Process for preparing difluorobenzo-1,3-dioxole-5-carboxylic acid derivatives | LANXESS DEUTSCHLAND GMBH (DE) | 2005-12-15 | — | — | US | disclosed |
| EP-1595876-A1 | Process for the preparation of derivatives of difluorobenzo-(1,3)-dioxole-5-carboxylic acid | Lanxess Deutschland GmbH (DE) | 2005-11-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11603351-B2 | Carboxamides as modulators of sodium channels | TRPV1, SCN2A, SCN10A | ALDH1A1 2665/4885TSHR 3163/4885TP53 4840/4885 |
| US-20210094906-A1 | CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | TRPV1, SCN2A, SCN10A | ALDH1A1 2665/4885TSHR 3163/4885TP53 4840/4885 |
| US-10647661-B2 | Carboxamides as modulators of sodium channels | TRPV1, SCN2A, SCN10A | ALDH1A1 2665/4885TSHR 3163/4885TP53 4840/4885 |
| US-20050277692-A1 | Process for preparing difluorobenzo-1,3-dioxole-5-carboxylic acid derivatives | BROX, DDT, DAO | ALDH1A1 351/4885TSHR 3905/4885TP53 929/4885 |
| US-20190016671-A1 | CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | TRPV1, SCN2A, SCN10A | ALDH1A1 2665/4885TSHR 3163/4885TP53 4840/4885 |
| US-20230286907-A1 | CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | TRPV1, SCN2A, SCN10A | ALDH1A1 2665/4885TSHR 3163/4885TP53 4840/4885 |
| US-12281057-B2 | Carboxamides as modulators of sodium channels | TRPV1, SCN2A, SCN10A | ALDH1A1 2665/4885TSHR 3163/4885TP53 4840/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.