Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.54 |
| ▸ | CACNA2D1 | P54289 | 10/20 | 0.53 |
| ▸ | CACNA1B | Q00975 | 10/20 | 0.53 |
| ▸ | CACNB1 | Q02641 | 10/20 | 0.53 |
| ▸ | CACNA1C | Q13936 | 9/20 | 0.53 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8445788 | 0.92 | FAAH (0.61) | FAAHCACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL5076791 | 0.82 | CACNA2D1 (0.75) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1H | |
| SCHEMBL10037140 | 0.82 | ACHE (0.61) | FAAHKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL16673587 | 0.76 | FAAH (0.71) | FAAHKDM4EALDH1A1LMNAMEN1 | |
| SCHEMBL5079984 | 0.74 | CACNA2D1 (0.73) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1H | |
| SCHEMBL26330969 | 0.73 | CACNA2D1 (0.81) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1H | |
| SCHEMBL18704998 | 0.72 | CACNA2D1 (0.58) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1H | |
| SCHEMBL18705047 | 0.71 | CACNA2D1 (0.57) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1H | |
| SCHEMBL3860589 | 0.71 | CACNA2D1 (0.69) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1H | |
| SCHEMBL26715447 | 0.71 | MEN1 (0.65) | FAAHKDM4EALDH1A1TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670775-A4 | PIPERAZINE SUBTITUTED COMPOUNDS USED AS CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD (CA) | 2009-04-22 | — | — | EP | claimed |
| JP-2007504174-A | — | — | 2007-03-01 | — | — | JP | claimed |
| EP-1670775-A1 | PIPERAZINE SUBTITUTED COMPOUNDS USED AS CALCIUM CHANNEL BLOCKERS | Neuromed Pharmaceuticals, Ltd. (CA) | 2006-06-21 | — | — | EP | claimed |
| WO-2005021523-A1 | PIPERAZINE SUBSTITUTED COMPOUNDS USED AS CALCIUM CHANNEL BLOCKERS | NEUROMED TECHNOLOGIES, INC. (CA) | 2005-03-10 | — | — | WO | claimed |