Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | CFD | P00746 | 1/20 | 0.35 |
| ▸ | TPSB2 | P20231 | 1/20 | 0.35 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 2/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | REN | P00797 | 1/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3864857 | 0.86 | HTR2C (0.39) | CHRNB4CHRNA3HTR2CHTR2BEGFR | |
| SCHEMBL3860277 | 0.85 | HTR2C (0.40) | CHRNB4CHRNA3HTR2CHTR2B | |
| SCHEMBL3863909 | 0.85 | CFD (0.37) | CFDTPSB2ASIC3BACE1HTR2A | |
| SCHEMBL235313 | 0.81 | HTR2C (0.34) | CHRNB4CHRNA3HTR2CHTR2BACACB | |
| SCHEMBL3870082 | 0.78 | HTR2A (0.46) | CFDTPSB2ASIC3HTR2A | |
| SCHEMBL3867999 | 0.76 | CFD (0.44) | CFDTPSB2ASIC3HTR2A | |
| SCHEMBL3865711 | 0.76 | CFD (0.45) | CFDTPSB2HTR2A | |
| SCHEMBL3964690 | 0.76 | CYP1A2 (0.43) | CFDTPSB2 | |
| SCHEMBL3968473 | 0.76 | MAPK1 (0.43) | CFDTPSB2ACACBPPARGPPARA | |
| SCHEMBL3860487 | 0.74 | PTGES (0.44) | CFDTPSB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076122-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2009005794-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-01-08 | — | — | WO | disclosed |