Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HAO1 | Q9UJM8 | 2/20 | 0.38 |
| ▸ | CFD | P00746 | 1/20 | 0.35 |
| ▸ | TPSB2 | P20231 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.33 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | ASIC3 | Q9UHC3 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15902652 | 0.82 | HTR2A (0.47) | HTR2ALMNAGRIK1GRIK2ALDH1A1 | |
| SCHEMBL3863909 | 0.82 | CFD (0.37) | HTR2ACFDTPSB2LMNAASIC3 | |
| SCHEMBL3864857 | 0.81 | HTR2C (0.39) | ASIC3 | |
| SCHEMBL3867999 | 0.81 | CFD (0.44) | HTR2ACFDTPSB2TRPA1ASIC3 | |
| SCHEMBL3865711 | 0.81 | CFD (0.45) | HTR2AHAO1CFDTPSB2KMT2A | |
| SCHEMBL3860277 | 0.80 | HTR2C (0.40) | — | |
| SCHEMBL3864997 | 0.78 | CHRNB4 (0.38) | HTR2ACFDTPSB2ASIC3 | |
| SCHEMBL232888 | 0.78 | HTR2A (0.40) | HTR2AHAO1LMNAASIC3KMT2A | |
| SCHEMBL15902347 | 0.77 | SCN4A (0.43) | HTR2ACFDTPSB2 | |
| SCHEMBL3862437 | 0.76 | HAO1 (0.41) | HAO1CFDTPSB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076122-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2009005794-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-01-08 | — | — | WO | disclosed |