Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 1/20 | 0.45 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 4/20 | 0.39 |
| ▸ | BTK | Q06187 | 2/20 | 0.39 |
| ▸ | CCNC | P24863 | 3/20 | 0.39 |
| ▸ | CDK8 | P49336 | 3/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12460416 | 0.80 | LRRK2 (0.49) | SMARCA2SMARCA4LRRK2MAP4K4BRD4 | |
| SCHEMBL12459916 | 0.78 | LRRK2 (0.51) | SMARCA2SMARCA4LRRK2MAP4K4BRD4 | |
| SCHEMBL12138433 | 0.78 | SMARCA2 (0.43) | SMARCA2SMARCA4LRRK2MAP4K4BRD4 | |
| SCHEMBL3702318 | 0.75 | LRRK2 (0.45) | SMARCA2SMARCA4LRRK2MAP4K4BRD4 | |
| SCHEMBL38650887 | 0.74 | SMARCA2 (0.46) | SMARCA2SMARCA4LRRK2MAP4K4GRM2 | |
| SCHEMBL24920665 | 0.73 | IRAK4 (0.47) | LRRK2KDRCHEK1FYNCSF1R | |
| SCHEMBL21753343 | 0.72 | MAPT (0.44) | LRRK2MAP4K4CCNCCDK8FYN | |
| SCHEMBL30274584 | 0.72 | CLK2 (0.43) | LRRK2BTKCHEK1AURKBAURKA | |
| SCHEMBL24007658 | 0.72 | CLK2 (0.43) | LRRK2BTKCHEK1AURKBAURKA | |
| SCHEMBL38650925 | 0.71 | SMARCA2 (0.65) | SMARCA2SMARCA4LRRK2MAP4K4BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122010963-A | Polycyclic SMARCA2 inhibitor and application thereof | 上海和誉生物医药科技有限公司 | 2026-05-12 | — | — | CN | disclosed |