Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28053028 | 0.99 | GRM5 (0.40) | GRM5HTTSMN1; SMN2MAPTMAPK1 | |
| SCHEMBL234656 | 0.86 | MTNR1A (0.49) | GRM5HTTSMN1; SMN2MAPTMAPK1 | |
| SCHEMBL236835 | 0.84 | HTT (0.39) | GRM5HTTSMN1; SMN2MAPTMAPK1 | |
| SCHEMBL236953 | 0.84 | SIGMAR1 (0.46) | GRM5MAPTPTGESMTNR1AMTNR1B | |
| SCHEMBL236875 | 0.84 | HTT (0.41) | GRM5HTTSMN1; SMN2MAPTMAPK1 | |
| SCHEMBL234119 | 0.84 | HTT (0.41) | GRM5HTTSMN1; SMN2MAPTMAPK1 | |
| SCHEMBL238182 | 0.84 | HTT (0.41) | GRM5HTTSMN1; SMN2MAPTMAPK1 | |
| SCHEMBL3843278 | 0.81 | PTGES (0.54) | SMN1; SMN2EPHX2LMNAPTGESKDM4E | |
| SCHEMBL236710 | 0.80 | HTT (0.38) | GRM5HTTSMN1; SMN2MAPTMAPK1 | |
| SCHEMBL232333 | 0.78 | HTT (0.41) | GRM5HTTSMN1; SMN2MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105541769-A | Alkynyl phenyl derivative compounds for treating ophthalmic diseases and disorders | ACUCELA INC | 2016-05-04 | — | — | CN | disclosed |
| CN-103664637-B | Be used for the treatment of ophthalmic diseases and disorderly alkynyl phenyl derivative compounds | ACUCELA INC. (US) | 2016-02-03 | — | — | CN | disclosed |
| EP-2076122-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2009005794-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-01-08 | — | — | WO | disclosed |