Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 2/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | ITGAL | P20701 | 2/20 | 0.39 |
| ▸ | MMP13 | P45452 | 2/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 7/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 4/20 | 0.38 |
| ▸ | ITGA5 | P08648 | 6/20 | 0.38 |
| ▸ | TMPRSS15 | P98073 | 3/20 | 0.38 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.38 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.38 |
| ▸ | ITGAV | P06756 | 2/20 | 0.37 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.37 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3868434 | 0.94 | PRSS1 (0.40) | PRSS1PRSS2PRSS3MAPK14CTSL | |
| SCHEMBL3869362 | 0.86 | ITGAL (0.49) | ITGALITGB1ITGA4ITGA5ITGB2 | |
| SCHEMBL3870809 | 0.86 | ITGAV (0.47) | PRSS1PRSS2PRSS3MAPK14ITGAL | |
| SCHEMBL3869880 | 0.81 | ITGAV (0.46) | MAPK14ITGALMMP13ITGB1ITGA4 | |
| SCHEMBL3876678 | 0.81 | ITGAL (0.48) | ITGALITGB1ITGA4ITGA5ITGB2 | |
| SCHEMBL3867932 | 0.81 | ITGAL (0.44) | ITGALITGB1ITGA4ITGA5ITGB2 | |
| SCHEMBL23978900 | 0.80 | FOLH1 (0.45) | PRSS1PRSS2PRSS3ITGALITGB1 | |
| SCHEMBL3871439 | 0.78 | ITGAL (0.51) | ITGALITGB1ITGA4ITGA5ITGB2 | |
| SCHEMBL16286432 | 0.78 | ITGAL (0.51) | ITGALITGB1ITGA4ITGA5ITGB2 | |
| SCHEMBL3866729 | 0.78 | ITGAL (0.51) | ITGALITGB1ITGA4ITGA5ITGB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7491741-B2 | Diaminopropionic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-02-17 | — | — | US | disclosed |
| US-20070155671-A1 | Diaminopropionic acid derivatives | FOTOUHI NADER | 2007-07-05 | — | — | US | disclosed |
| US-7217728-B2 | Diaminopropionic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 2007-05-15 | — | — | US | disclosed |
| US-20050080119-A1 | Diaminopropionic acid derivatives | FOTOUHI NADER (US) | 2005-04-14 | — | — | US | disclosed |
| US-6803384-B2 | FOR THERAPY OF REPERFUSION INJURY | HOFFMANN-LA ROCHE INC. | 2004-10-12 | — | — | US | disclosed |
| US-20040006236-A1 | Diaminopropionic acid derivatives | FOTOUHI NADER (US) | 2004-01-08 | — | — | US | disclosed |
| US-20020052512-A1 | Diaminopropionic acid derivatives | FOTOUHI NADER (US) | 2002-05-02 | — | — | US | disclosed |
| US-6331640-B1 | TREATMENT OF REPERFUSION INJURIES | HOFFMANN-LA ROCHE INC. | 2001-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040006236-A1 | Diaminopropionic acid derivatives | AIFM1, AIFM2, HIF1A | PRSS1 2680/4885PRSS2 4219/4885PRSS3 4210/4885 |
| US-20020052512-A1 | Diaminopropionic acid derivatives | AIFM1, AIFM2, HIF1A | PRSS1 2680/4885PRSS2 4219/4885PRSS3 4210/4885 |
| US-20070155671-A1 | Diaminopropionic acid derivatives | AIFM1, HIF1A, AIFM2 | PRSS1 3058/4885PRSS2 4205/4885PRSS3 4200/4885 |
| US-20050080119-A1 | Diaminopropionic acid derivatives | AIFM1, HIF1A, AIFM2 | PRSS1 3058/4885PRSS2 4205/4885PRSS3 4200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.