SCHEMBL38664280

SCHEMBL38664280

Clc1cc(Br)cc2c(I)n[nH]c12

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHEK1 O14757 2/20 0.39
FLT3 P36888 1/20 0.39
PLK3 Q9H4B4 1/20 0.39
JAK2 O60674 2/20 0.32
PDPK1 O15530 1/20 0.32
NMT1 P30419 1/20 0.31
AURKA O14965 1/20 0.30
DAPK3 O43293 1/20 0.30
MAP4K4 O95819 1/20 0.30
PAK4 O96013 1/20 0.30
ABL1 P00519 1/20 0.30
CSF1R P07333 1/20 0.30
RET P07949 1/20 0.30
IGF1R P08069 1/20 0.30
FGFR1 P11362 1/20 0.30
PDGFRA P16234 1/20 0.30
PRKACA P17612 1/20 0.30
FLT1 P17948 1/20 0.30
LTK P29376 1/20 0.30
GRK5 P34947 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26204533 1.00 CHEK1 (0.39) CHEK1FLT3PLK3JAK2PDPK1
SCHEMBL14030589 0.82 ALDH1A1 (0.33) CHEK1JAK2PDPK1AURKADAPK3
SCHEMBL20487931 0.81 GSK3B (0.34) CHEK1JAK2PDPK1AURKADAPK3
SCHEMBL1144559 0.79 ADORA2A (0.42) CHEK1FLT3PLK3JAK2PDPK1
SCHEMBL38661124 0.79 PDPK1 (0.31) JAK2PDPK1
SCHEMBL38664283 0.77 DYRK1B (0.35) DYRK1B
SCHEMBL1144823 0.75 CYP1A2 (0.32) CHEK1FLT3PLK3
SCHEMBL25315454 0.75 EPRS1 (0.32)
SCHEMBL20488776 0.75
SCHEMBL20488994 0.75 CHEK1 (0.32) CHEK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026101971-A2 EGFR INHIBITORS FOR TREATING DISEASE BLOSSOMHILL THERAPEUTICS, INC. (US) 2026-05-15 WO disclosed