ITPR1

Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 · Q14643 · ITPR1 on Sugi Atlas →

1,659 patent compounds predicted against ITPR1, 1,070 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Ins(1,4,5)P3 (SCHEMBL98182)	1.00	5/20
Ins(1,4,5)P3 (SCHEMBL381458)	1.00	5/20
Ins(1,4,5)P3 (SCHEMBL382820)	1.00	5/20
Ins(1,4,5)P3 (SCHEMBL4321735)	1.00	5/20
Ins(1,4,5)P3 (SCHEMBL4871682)	1.00	5/20
Ins(1,4,5)P3 (SCHEMBL4874594)	1.00	5/20
Ins(1,4,5)P3 (SCHEMBL9382320)	1.00	5/20
Ins(1,4,5)P3 (SCHEMBL9383914)	1.00	5/20
Ins(1,4,5)P3 (SCHEMBL10490812)	1.00	5/20
SCHEMBL1569348	0.81	5/20
SCHEMBL2724650	0.81	5/20
SCHEMBL7434973	0.78	5/20
SCHEMBL8914116	0.78	5/20
SCHEMBL10344783	0.78	5/20
SCHEMBL5184816	0.77	5/20
SCHEMBL6664274	0.74	5/20
SCHEMBL7431054	0.69	5/20
SCHEMBL7433563	0.69	5/20
SCHEMBL7436779	0.69	5/20
SCHEMBL7436980	0.69	5/20

Clinical trials — most relevant to ITPR1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Magnesium Administration in Liver Transplantation and Reperfusion Injury	PHASE4	COMPLETED
The Effect of Protein on Calcium Absorption and Gastric Acid Production	PHASE4	COMPLETED
Myo-inositol for the Management of Poor Ovarian Responders: A Prospective Randomized Controlled Trial	PHASE2/PHASE3	UNKNOWN
Role of Intralipid in Management of Organophosphorus Poisoning	PHASE2/PHASE3	WITHDRAWN
Can Calcium Ionophore Application Enhance the ICSI Outcomes in Severe Male Factor Infertility?	PHASE2/PHASE3	UNKNOWN
Sodium Citrate in Smell Retraining for People With Post-COVID-19 Olfactory Dysfunction	PHASE2	ACTIVE_NOT_RECRUITING
A Phase I/II, First-In-Human Trial to Evaluate the Safety, Tolerability, and Pharmacokinetic Activity to Prevent or Treat Neuropsychiatric Symptoms in Pediatric Subjects With Timothy Syndrome	PHASE1/PHASE2	NOT_YET_RECRUITING
Study Evaluating Toxicity & Efficacy of Lenalidomide(Revlimid®)in Chemotherapy-Naïve AIPC Patients	PHASE2	COMPLETED
Calcium Channel Blockade in Primary Aldosteronism	PHASE2	COMPLETED
Bioequivalence Study of Tacrolimus in Healthy Volunteers	PHASE1	COMPLETED
PET Brain and Whole Body Distribution Studies for Nociceptin/Orphanin FQ Peptide (NOP) Receptor Using [11C]NOP-1A	EARLY_PHASE1	COMPLETED
Clinical Study Evaluating the Effect of Losartan	nan	RECRUITING
The Energetic Origin of Neurodegeneration in MS	nan	COMPLETED
The Study Aims to Investigate the Effects of Oral Inositols on Insulin-resistance in Children With Obesity.	nan	UNKNOWN
Study of the Pathophysiological Mechanisms Involved in Bleeding Events	nan	COMPLETED
Early Detection of Cardiomyopathy by Speckle Echo, High Sensitive Troponin and Cardiac Ryanodine Receptors	nan	UNKNOWN
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia	nan	RECRUITING
Evaluation of Plasma Sphingosine-1-Phosphate as A Diagnostic and Prognostic Biomarkers of Community-Acquired Pneumonia	nan	UNKNOWN
Oxidative Stress in Women Treated With Atosiban for Impending Preterm Birth	nan	COMPLETED
Molecular Markers of Human Sperm Function	nan	WITHDRAWN
An Epidemiological Study of Subjects With Immune Thrombocytopenic Purpura to Evaluate the Relationship Between Platelet Counts, Endogenous Thrombopoietin Levels, Endogenous Anti-Thrombopoietin Antibodies, and Selected Autoimmune Markers	nan	COMPLETED
Parathyroid Hormone (PTH) Homeostasis in Bartter Syndrome	nan	UNKNOWN
Intra-cortical Inhibition and Cognitive Deficits in Schizophrenia	nan	UNKNOWN
Genomic Landscape of Intramedullary Astrocytoma	nan	UNKNOWN
Regulation of Vitamin D Receptor (VDR),Calcium Sensing Receptor (CaSR), Cyclin D1,Ki67 and Proliferating Cell Nuclear Antigen (PCNA) in Primary Hyperparathyroidism	nan	UNKNOWN
Sodium Channel Splicing in Heart Failure Trial	nan	COMPLETED
Effects of Photobiomodulation on the Innate Immune System of Neonates and Infants With Bronchiolitis	nan	UNKNOWN
Role of Amino Acids and Genetic Disorder in Pathogenesis of Heart Failure	nan	UNKNOWN
Molecular and Cellular Characterization of Cardiac Tissue in Postnatal Development	nan	RECRUITING
The Prevalence of RYR1-related Disease	nan	NOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a ITPR1 binder may also engage these)

Protein	Name	Similarity
P29994	—	1.000	P29994 →
Q9TU34	—	1.000	Q9TU34 →
P11881	—	1.000	P11881 →
ITPR2	Inositol 1,4,5-trisphosphate-gated calcium ch	1.000	landscape →
ITPR3	Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3	1.000	landscape →
Q8WN96	—	1.000	Q8WN96 →
P29995	—	1.000	P29995 →
Q9Z329	—	1.000	Q9Z329 →
Q8WN95	—	1.000	Q8WN95 →
Q8WSR4	—	0.998	Q8WSR4 →
P70227	—	0.998	P70227 →
Q63269	—	0.995	Q63269 →
DNAJC13	DnaJ homolog subfamily C member 13	0.988	landscape →
Q24498	—	0.986	Q24498 →
P29993	—	0.985	P29993 →
P30957	—	0.984	P30957 →
Q6A026	—	0.983	Q6A026 →
RYR2	Ryanodine receptor 2	0.982	landscape →
Q5R6J0	—	0.981	Q5R6J0 →
B0LPN4	—	0.981	B0LPN4 →
O35099	—	0.981	O35099 →
ECPAS	Proteasome adapter and scaffold protein ECM29	0.980	landscape →
Q7TMY8	—	0.980	Q7TMY8 →
E9Q401	—	0.980	E9Q401 →
PDS5A	Sister chromatid cohesion protein PDS5 homolog A	0.980	landscape →
Q8IZQ1	—	0.979	Q8IZQ1 →
A4L9P7	—	0.979	A4L9P7 →
Q4VA53	—	0.979	Q4VA53 →
Q5F3U9	—	0.979	Q5F3U9 →
Q8TAP6	—	0.979	Q8TAP6 →