Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 11/20 | 0.68 |
| ▸ | NPC1 | O15118 | 9/20 | 0.68 |
| ▸ | RAB9A | P51151 | 9/20 | 0.68 |
| ▸ | MAPT | P10636 | 7/20 | 0.68 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.68 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.68 |
| ▸ | RELA | Q04206 | 4/20 | 0.68 |
| ▸ | TP53 | P04637 | 10/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | USP2 | O75604 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12692485 | 0.98 | SMN1; SMN2 (0.70) | SMN1; SMN2NPC1RAB9AMAPTNFKB1 | |
| 2-Phenylthiazole SCHEMBL18894653 | 0.82 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1RAB9AMAPTNFKB1 | |
| SCHEMBL5773733 | 0.82 | TP53 (0.68) | SMN1; SMN2NPC1RAB9AMAPTNFKB1 | |
| SCHEMBL1728599 | 0.82 | SMN1; SMN2 (0.66) | SMN1; SMN2NPC1RAB9AMAPTNFKB1 | |
| SCHEMBL30059210 | 0.82 | NPC1 (0.66) | SMN1; SMN2NPC1RAB9AMAPTNFKB1 | |
| SCHEMBL4147815 | 0.82 | NPC1 (0.66) | SMN1; SMN2NPC1RAB9AMAPTNFKB1 | |
| SCHEMBL969616 | 0.82 | NPC1 (0.66) | SMN1; SMN2NPC1RAB9AMAPTNFKB1 | |
| SCHEMBL12970198 | 0.82 | NPC1 (0.66) | SMN1; SMN2NPC1RAB9AMAPTNFKB1 | |
| SCHEMBL1692138 | 0.82 | NPC1 (0.66) | SMN1; SMN2NPC1RAB9AMAPTNFKB1 | |
| SCHEMBL5301366 | 0.82 | SMN1; SMN2 (0.62) | SMN1; SMN2NPC1RAB9AMAPTNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601846-B2 | Compounds having activity as inhibitors of apoptosis | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-10-13 | — | — | US | disclosed |
| US-20060122178-A1 | Compounds having activity as inhibitors of apoptosis | REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | 2006-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122178-A1 | Compounds having activity as inhibitors of apoptosis | BAD, CASP3, BAX | SMN1; SMN2 3506/4885NPC1 2532/4885RAB9A 3287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.