Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | GAK | O14976 | 2/20 | 0.33 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.33 |
| ▸ | COQ8A | Q8NI60 | 2/20 | 0.33 |
| ▸ | NLK | Q9UBE8 | 2/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18078827 | 0.85 | MBOAT4 (0.40) | CCNCCDK8MBOAT4CLK4GRM5 | |
| SCHEMBL30607265 | 0.85 | MBOAT4 (0.40) | CCNCCDK8MBOAT4CLK4GRM5 | |
| Hydrochloric Acid SCHEMBL29088315 | 0.83 | MBOAT4 (0.39) | CCNCCDK8MBOAT4CLK4GRM5 | |
| SCHEMBL3870198 | 0.81 | CCNC (0.40) | CCNCCDK8MBOAT4CLK4LMNA | |
| SCHEMBL7219031 | 0.81 | KDM4E (0.49) | CCNCCDK8MBOAT4LMNACYP19A1 | |
| SCHEMBL4963448 | 0.79 | MBOAT4 (0.40) | CCNCCDK8MBOAT4LMNACYP19A1 | |
| SCHEMBL22637777 | 0.77 | MBOAT4 (0.39) | CCNCCDK8MBOAT4CLK4PDE5A | |
| SCHEMBL29069480 | 0.77 | CCNC (0.37) | CCNCCDK8MBOAT4CLK4LMNA | |
| SCHEMBL13738243 | 0.77 | CCNC (0.37) | CCNCCDK8MBOAT4CLK4LMNA | |
| SCHEMBL481078 | 0.77 | NOTUM (0.43) | CCNCCDK8MBOAT4CLK4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069364-A1 | NOVEL 5, 7-DISUBSTITUTED [1, 3]THIAZOLO [4, 5-D]PYRIMIDIN-2 (3H)-ONE DERIVATIVES AND THEIR USE IN THERAPY | AstraZeneca AB (SE) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008039138-A1 | NOVEL 5, 7-DISUBSTITUTED [1, 3 ] THIAZOLO [4, 5-D] PYRIMIDIN-2 (3H)-ONE DERIVATIVES AND THEIR USE IN THERAPY | ASTRAZENECA AB (SE) | 2008-04-03 | — | — | WO | disclosed |