Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.30 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3865804 | 0.84 | REN (0.35) | REN | |
| SCHEMBL611418 | 0.83 | REN (0.34) | RENGRM2GRM3 | |
| SCHEMBL3859919 | 0.82 | REN (0.31) | RENGRM2GRM3 | |
| SCHEMBL3843317 | 0.82 | KIF11 (0.37) | — | |
| SCHEMBL10237699 | 0.81 | REN (0.35) | RENGRM2GRM3 | |
| SCHEMBL613098 | 0.79 | REN (0.35) | RENGRM2GRM3 | |
| SCHEMBL3836935 | 0.78 | NOS1 (0.34) | — | |
| SCHEMBL232923 | 0.74 | CYP2D6 (0.33) | — | |
| SCHEMBL3862238 | 0.74 | TAAR1 (0.40) | — | |
| SCHEMBL18097919 | 0.73 | CYP2D6 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076122-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2009005794-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-01-08 | — | — | WO | disclosed |