Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | PLAT | P00750 | 2/20 | 0.34 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.34 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.34 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.34 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.34 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.34 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3872584 | 0.92 | NPSR1 (0.36) | NPSR1HSD17B10SMN1; SMN2NPC1MITF | |
| SCHEMBL3870875 | 0.84 | TSHR (0.40) | NPSR1SMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL6904311 | 0.75 | KMT2A (0.39) | NPSR1NPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL6903139 | 0.70 | RXFP1 (0.41) | NPSR1HSD17B10NPC1RAB9AALDH1A1 | |
| SCHEMBL3869104 | 0.69 | ALOX5 (0.58) | NPSR1HSD17B10SMN1; SMN2NPC1MITF | |
| SCHEMBL5143038 | 0.69 | KDM4E (0.51) | HSD17B10SMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL10771130 | 0.67 | NPC1 (0.37) | NPSR1HSD17B10SMN1; SMN2NPC1MITF | |
| SCHEMBL1344567 | 0.67 | HSD17B10 (0.46) | NPSR1HSD17B10SMN1; SMN2NPC1MITF | |
| SCHEMBL25069322 | 0.66 | GABRA1 (0.54) | HSD17B10TP53ALDH1A1KDM4EHPGD | |
| SCHEMBL30938469 | 0.65 | KDM4E (0.37) | NPSR1HSD17B10SMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013182-A2 | AMINOQUINOLONES AS GSK-3 INHIBITORS | Activx Biosciences, Inc. (US) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007106537-A2 | AMINOQUINOLONES AS GSK-3 INHIBITORS | ACTIVX BIOSCIENCES, INC. (US) | 2007-09-20 | — | — | WO | disclosed |