Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 9/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4080919 | 0.92 | ALOX5 (0.54) | ALOX5SMN1; SMN2MAPTTDP1L3MBTL1 | |
| SCHEMBL3878774 | 0.89 | ALOX5 (0.53) | ALOX5SMN1; SMN2MAPTTDP1L3MBTL1 | |
| SCHEMBL5716973 | 0.81 | ALOX5 (0.58) | ALOX5NPC1ALOX15GABRA1GABRB1 | |
| SCHEMBL3872372 | 0.77 | ALOX5 (0.38) | ALOX5L3MBTL1NPC1RAB9AKMT2A | |
| SCHEMBL3870848 | 0.69 | NPSR1 (0.41) | SMN1; SMN2NPC1RAB9AHSD17B10MITF | |
| SCHEMBL1344580 | 0.69 | TSHR (0.49) | SMN1; SMN2MAPTTDP1KMT2AKDM4E | |
| SCHEMBL25069322 | 0.67 | GABRA1 (0.54) | MAPTL3MBTL1HSD17B10TP53KMT2A | |
| SCHEMBL15175923 | 0.67 | NPC1 (0.51) | ALOX5SMN1; SMN2MAPTTDP1L3MBTL1 | |
| SCHEMBL8529906 | 0.65 | ALOX5 (0.52) | ALOX5SMN1; SMN2MAPTTDP1L3MBTL1 | |
| SCHEMBL8885867 | 0.65 | ALOX5 (0.49) | ALOX5SMN1; SMN2MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013182-A2 | AMINOQUINOLONES AS GSK-3 INHIBITORS | Activx Biosciences, Inc. (US) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007106537-A2 | AMINOQUINOLONES AS GSK-3 INHIBITORS | ACTIVX BIOSCIENCES, INC. (US) | 2007-09-20 | — | — | WO | disclosed |