Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Flucytosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HBB | P68871 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Flucytosine SCHEMBL24063 | 0.98 | — | — | |
| Flucytosine SCHEMBL8160959 | 0.98 | ALDH1A1 (0.37) | ALDH1A1LMNAMAPTCYP19A1TSHR | |
| Flucytosine SCHEMBL28748160 | 0.96 | — | — | |
| Flucytosine SCHEMBL29100530 | 0.96 | ALDH1A1 (0.35) | ALDH1A1LMNAMAPTCYP19A1TSHR | |
| Flucytosine SCHEMBL3871370 | 0.96 | ALDH1A1 (0.35) | ALDH1A1LMNAMAPTCYP19A1TSHR | |
| Flucytosine SCHEMBL3869716 | 0.96 | ALDH1A1 (0.35) | ALDH1A1LMNAMAPTCYP19A1TSHR | |
| Flucytosine SCHEMBL3868918 | 0.96 | ALDH1A1 (0.35) | ALDH1A1LMNAMAPTCYP19A1TSHR | |
| Flucytosine SCHEMBL1050449 | 0.94 | ALDH1A1 (0.34) | ALDH1A1LMNAMAPTCYP19A1TSHR | |
| Flucytosine SCHEMBL3867430 | 0.92 | ALDH1A1 (0.33) | ALDH1A1LMNAMAPTCYP19A1TSHR | |
| Flucytosine SCHEMBL27696081 | 0.92 | ALDH1A1 (0.33) | ALDH1A1LMNAMAPTCYP19A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090068287-A1 | Novel topical formulations of flucytosine and uses thereof | CAMARGO PHARMACEUTICAL SERVICES LLC | 2009-03-12 | — | — | US | claimed |
| EP-0413246-A2 | Reparation of parenteral forms, their application in a kit and 5-Fluorcytosin-Monochlorhydrate | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1991-02-20 | — | — | EP | claimed |
| JP-3090019-A | — | — | None | — | — | JP | disclosed |
| CN-108586268-A | N, the method for accelerine recycling are recycled in a kind of Flucytosine chlorinated effluent | 精华制药集团南通有限公司 | 2018-09-28 | — | — | CN | disclosed |
| US-20090068287-A1 | Novel topical formulations of flucytosine and uses thereof | CAMARGO PHARMACEUTICAL SERVICES LLC | 2009-03-12 | — | — | US | disclosed |
| JP-H0390019-A | PREPARATION OF PARENTERALLY ADMINISTRABLE SOLUTION OF PHARMACEUTICALLY ACTIVE SUBSTANCE | F HOFFMANN LA ROCHE AG | 1991-04-16 | — | — | JP | disclosed |
| EP-0413246-A2 | Reparation of parenteral forms, their application in a kit and 5-Fluorcytosin-Monochlorhydrate | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1991-02-20 | — | — | EP | disclosed |
| EP-0413246-A2 | Reparation of parenteral forms, their application in a kit and 5-Fluorcytosin-Monochlorhydrate | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1991-02-20 | — | — | EP | disclosed |