Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Flucytosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HBB | P68871 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Flucytosine SCHEMBL24063 | 1.00 | — | — | |
| Flucytosine SCHEMBL3868918 | 0.98 | ALDH1A1 (0.35) | ALDH1A1LMNAMAPTCYP19A1TSHR | |
| Flucytosine SCHEMBL28748160 | 0.98 | — | — | |
| Flucytosine SCHEMBL29100530 | 0.98 | ALDH1A1 (0.35) | ALDH1A1LMNAMAPTCYP19A1TSHR | |
| Flucytosine SCHEMBL3871370 | 0.98 | ALDH1A1 (0.35) | ALDH1A1LMNAMAPTCYP19A1TSHR | |
| Flucytosine SCHEMBL3869716 | 0.98 | ALDH1A1 (0.35) | ALDH1A1LMNAMAPTCYP19A1TSHR | |
| Flucytosine SCHEMBL3870974 | 0.98 | ALDH1A1 (0.35) | ALDH1A1LMNAMAPTCYP19A1TSHR | |
| Flucytosine SCHEMBL1050449 | 0.96 | ALDH1A1 (0.34) | ALDH1A1LMNAMAPTCYP19A1TSHR | |
| Flucytosine SCHEMBL3867430 | 0.94 | ALDH1A1 (0.33) | ALDH1A1LMNAMAPTCYP19A1TSHR | |
| Flucytosine SCHEMBL27696081 | 0.94 | ALDH1A1 (0.33) | ALDH1A1LMNAMAPTCYP19A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1960781-A | Therapeutic combination for treatment of alzheimers disease | WARNER LAMBERT CO (US) | 2007-05-09 | — | — | CN | disclosed |
| EP-1032263-A1 | SURFACTANT-BASED ANTIMICROBIAL COMPOSITIONS AND METHODS FOR USING SAME | Woodward Laboratories Inc. (US) | 2000-09-06 | — | — | EP | disclosed |
| US-6087400-A | MIXTURE CONTAINING BENZALKONIUM CHLORIDE AND WATER | WOODWARD LABORATORIES, INC. (US) | 2000-07-11 | — | — | US | disclosed |
| US-6013677-A | APPLYING TO THE NAIL A NON-AQUEOUS ANTIMICROBIAL NAIL COATING CONTAINING A FILM FORMING POLYMER, AN ORGANIC SOLVENT, A ANTIMICROBIAL AGENT COMPRISING SOLUBILZED BENZALKONIUM CHLORIDE AND CAPABLE OF LEACHING FROM NAIL COATING | WOODWARD LABORATORIES, INC. (US) | 2000-01-11 | — | — | US | disclosed |
| US-5994383-A | MIXTURE CONTAINING BENZALKONIUM CHLORIDE AND WATER | WOODWARD LABORATORIES, INC. (US) | 1999-11-30 | — | — | US | disclosed |
| WO-1999036033-A1 | ANTIMICROBIAL NAIL COATING COMPOSITION | WOODWARD LABORATORIES, INC. (US) | 1999-07-22 | — | — | WO | disclosed |
| WO-1999025190-A1 | SURFACTANT-BASED ANTIMICROBIAL COMPOSITIONS AND METHODS FOR USING SAME | WOODWARD LABORATORIES, INC. (US) | 1999-05-27 | — | — | WO | disclosed |
| WO-1996030011-A1 | TOPICAL ANTIMYCOTIC COMPOSITIONS | BIOPLEX, L.C. (US) | 1996-10-03 | — | — | WO | disclosed |