Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.57 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.52 |
| ▸ | NR1I3 | Q14994 | 2/20 | 0.52 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | CXCL8 | P10145 | 4/20 | 0.42 |
| ▸ | CLIC1 | O00299 | 1/20 | 0.42 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.42 |
| ▸ | CAMK2A | Q9UQM7 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.36 |
| ▸ | UGT1A9 | O60656 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
| ▸ | ALB | P02768 | 1/20 | 0.36 |
| ▸ | UGT1A6 | P19224 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3870137 | 0.95 | PTGS2 (0.49) | PTGS2ABCB11PTGS1NR1I3PPARG | |
| SCHEMBL3876179 | 0.92 | PTGS2 (0.66) | PTGS2ABCB11PTGS1NR1I3PPARG | |
| SCHEMBL3881380 | 0.90 | PTGS2 (0.56) | PTGS2ABCB11PTGS1NR1I3PPARG | |
| SCHEMBL3881581 | 0.89 | PTGS2 (0.47) | PTGS2ABCB11PTGS1NR1I3PPARG | |
| SCHEMBL5082240 | 0.85 | PTGS2 (0.52) | PTGS2ABCB11PTGS1NR1I3PPARG | |
| SCHEMBL3873443 | 0.85 | PTGS2 (0.49) | PTGS2ABCB11PTGS1NR1I3PPARG | |
| SCHEMBL10316744 | 0.84 | PTGS2 (0.54) | PTGS2ABCB11PTGS1NR1I3PPARG | |
| SCHEMBL3881389 | 0.83 | PTGS2 (0.46) | PTGS2ABCB11PTGS1NR1I3PPARG | |
| SCHEMBL3871234 | 0.83 | PTGS2 (0.62) | PTGS2ABCB11PTGS1NR1I3PPARG | |
| SCHEMBL4312160 | 0.83 | P2RX7 (0.40) | PTGS2ABCB11PTGS1NR1I3PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046723-A2 | PHENYLACETIC ACID DERIVATIVES AS COX-2 INHIBITORS | Novartis AG (CH) | 2009-04-15 | — | — | EP | claimed |
| WO-2008002853-A2 | PHENYLACETIC ACID DERIVATIVES AS COX-2 INHIBITORS | NOVARTIS AG (CH) | 2008-01-03 | — | — | WO | claimed |