Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.62 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.56 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.56 |
| ▸ | HTR2A | P28223 | 4/20 | 0.56 |
| ▸ | GPR183 | P32249 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3872694 | 1.00 | TNIK (0.62) | TNIKCHRM1MCHR1HTR2AGPR183 | |
| SCHEMBL3872695 | 1.00 | TNIK (0.62) | TNIKCHRM1MCHR1HTR2AGPR183 | |
| SCHEMBL3869109 | 0.91 | MCHR1 (0.67) | TNIKCHRM1MCHR1HTR2ANPC1 | |
| SCHEMBL3869105 | 0.91 | MCHR1 (0.67) | TNIKCHRM1MCHR1HTR2ANPC1 | |
| SCHEMBL3869111 | 0.91 | MCHR1 (0.67) | TNIKCHRM1MCHR1HTR2ANPC1 | |
| SCHEMBL13646597 | 0.78 | KDM4E (0.58) | CHRM1MCHR1HTR2AGPR183SMN1; SMN2 | |
| SCHEMBL28663251 | 0.77 | RAB9A (0.76) | CHRM1MCHR1HTR2ANPC1GAA | |
| SCHEMBL22079996 | 0.77 | RAB9A (0.76) | CHRM1MCHR1HTR2ANPC1GAA | |
| Hydrochloric Acid SCHEMBL3869054 | 0.77 | ALDH1A1 (0.57) | CHRM1MCHR1HTR2AGPR183SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL3869056 | 0.77 | ALDH1A1 (0.57) | CHRM1MCHR1HTR2AGPR183SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601868-B2 | Such as 4-(cyclopropylmethoxy)-N-(2-{4-[1-(1-pyrrolidinyl)ethyl]phenyl}ethyl)benzamide having melanin-concentrating hormone antagonistic action, for prophylaxis and/or treatment of obesity | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-10-13 | — | — | US | disclosed |
| US-20060128690-A1 | Amine derivative | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-06-15 | — | — | US | disclosed |
| EP-1593667-A1 | AMINE DERIVATIVE | Takeda Pharmaceutical Company Limited (JP) | 2005-11-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060128690-A1 | Amine derivative | MC1R, MC2R, MC4R | TNIK 4677/4885CHRM1 217/4885MCHR1 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.