Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | NCF1 | P14598 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19211801 | 0.80 | GRM5 (0.53) | GRM5KMT2AGAANOS3NOS2 | |
| SCHEMBL29595780 | 0.80 | GRM5 (0.53) | GRM5KMT2AGAANOS3NOS2 | |
| SCHEMBL15750954 | 0.79 | IDO1 (0.33) | GRM5 | |
| SCHEMBL3872323 | 0.74 | GRM5 (0.68) | GRM5KMT2ASLC6A2KDM4ELMNA | |
| SCHEMBL21816291 | 0.74 | GRM5 (0.46) | GRM5KMT2AGAANOS3NOS2 | |
| SCHEMBL3060800 | 0.74 | GRM5 (0.46) | GRM5KMT2AGAANOS3NOS2 | |
| Hydrochloric Acid SCHEMBL3879152 | 0.73 | GRM5 (0.66) | GRM5KMT2ASLC6A2KDM4ELMNA | |
| SCHEMBL20433364 | 0.72 | NOS3 (0.35) | GRM5NOS3NOS2KDM4E | |
| SCHEMBL3872237 | 0.72 | GRM5 (0.68) | GRM5KMT2ASLC6A2KDM4ELMNA | |
| SCHEMBL1695597 | 0.71 | CYP1A2 (0.49) | KMT2AGAAKDM4ELMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2028180-A1 | Novel aminopyridine derivatives as mGluR5 antagonists | ADDEX Pharma S.A. (CH) | 2009-02-25 | — | — | EP | disclosed |
| EP-1603877-B1 | NOVEL AMINOPYRIDINE DERIVATIVES AS mGIuR5 ANTAGONISTS | ADDEX PHARMA SA (CH) | 2008-11-26 | — | — | EP | disclosed |
| US-20080004316-A1 | Novel aminopyridine derivatives as mGluR5 antagonists | ADDEX PHARMACEUTICALS SA (CH) | 2008-01-03 | — | — | US | disclosed |
| US-7205411-B2 | Aminopyridine derivatives as mGluR5 antagonists | ADDEX PHARMACEUTICALS SA (CH) | 2007-04-17 | — | — | US | disclosed |
| US-20060183758-A1 | Method for synthesis of AZA-annelated pyrroles, thiophenes, and furans | CB RESEARCH AND DEVELOPMENT, INC. (US) | 2006-08-17 | — | — | US | disclosed |
| US-20060030601-A1 | Novel aminopyridine derivatives as mGluR5 antagonists | ADDEX PHARMACEUTICALS SA (CH) | 2006-02-09 | — | — | US | disclosed |
| EP-1603877-A1 | NOVEL AMINOPYRIDINE DERIVATIVES AS mGIuR5 ANTAGONISTS | Addex Pharmaceuticals SA (CH) | 2005-12-14 | — | — | EP | disclosed |
| WO-2004078728-A1 | NOVEL AMINOPYRIDINE DERIVATIVES AS mGIuR5 ANTAGONISTS | ADDEX PHARMACEUTICALS SA (CH) | 2004-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004316-A1 | Novel aminopyridine derivatives as mGluR5 antagonists | GRM5, GRM6, GRM2 | GRM5 1/4885KMT2A 1304/4885GAA 4648/4885 |
| US-20060030601-A1 | Novel aminopyridine derivatives as mGluR5 antagonists | GRM5, GRM6, GRM2 | GRM5 1/4885KMT2A 1304/4885GAA 4648/4885 |
| US-20060183758-A1 | Method for synthesis of AZA-annelated pyrroles, thiophenes, and furans | TPMT, INMT, AANAT | GRM5 2181/4885KMT2A 1936/4885GAA 3525/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.