Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 8/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.41 |
| ▸ | CNR2 | P34972 | 10/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3461135 | 0.85 | PIK3CD (0.47) | HDAC4HDAC6CNR2 | |
| SCHEMBL3852663 | 0.79 | RAB9A (0.46) | — | |
| SCHEMBL3873906 | 0.72 | CNR2 (0.39) | HDAC4HDAC6CNR2 | |
| SCHEMBL3460789 | 0.68 | PLK1 (0.50) | — | |
| SCHEMBL3837215 | 0.67 | ATR (0.41) | HDAC6HDAC8 | |
| SCHEMBL17664669 | 0.66 | HDAC6 (0.41) | HDAC4HDAC6HDAC1HDAC8 | |
| SCHEMBL27152577 | 0.66 | P4HA1 (0.53) | HDAC4HDAC6CNR2HDAC1 | |
| SCHEMBL3462777 | 0.66 | ATR (0.51) | — | |
| SCHEMBL20043166 | 0.66 | CNR2 (0.48) | HDAC4HDAC6CNR2 | |
| SCHEMBL3459736 | 0.64 | ATR (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501514-A4 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2009-08-26 | — | — | EP | disclosed |
| EP-1501514-A2 | PROTEIN KINASE MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003093297-A2 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2003-11-13 | — | — | WO | disclosed |