Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.82 |
| ▸ | PDE9A | O76083 | 1/20 | 0.45 |
| ▸ | PDE1A | P54750 | 1/20 | 0.45 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.45 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PNP | P00491 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL37798 | 0.90 | PDE5A (1.00) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL37626 | 0.88 | PDE5A (0.80) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL46289 | 0.85 | PDE5A (0.76) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL38530 | 0.84 | PDE5A (0.73) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL38743 | 0.83 | PDE5A (0.82) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL38312 | 0.81 | PDE5A (0.70) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL38275 | 0.80 | PDE5A (0.69) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL37584 | 0.80 | PDE5A (0.66) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL37513 | 0.78 | PDE5A (0.79) | PDE5AKDM4EKMT2A | |
| SCHEMBL37583 | 0.78 | PDE5A (0.78) | PDE5AKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012004900-A1 | THIENOPYRIMIDINE COMPOUNDS | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2012-01-12 | — | — | WO | disclosed |