Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 18/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL387648 | 0.91 | GPR119 (0.64) | GPR119HDAC1CYP4F2CYP4A11 | |
| SCHEMBL870413 | 0.90 | GPR119 (0.71) | GPR119CYP4F2CYP4A11 | |
| Trifluoroacetic Acid SCHEMBL387465 | 0.89 | GPR119 (0.63) | GPR119HDAC1CYP4F2CYP4A11 | |
| SCHEMBL870088 | 0.87 | GPR119 (0.69) | GPR119HDAC1CYP4F2CYP4A11 | |
| SCHEMBL387205 | 0.81 | GPR119 (0.77) | GPR119CYP4F2CYP4A11 | |
| SCHEMBL14191021 | 0.80 | GPR119 (0.71) | GPR119HDAC1CYP4F2CYP4A11 | |
| SCHEMBL387461 | 0.80 | GPR119 (0.72) | GPR119CYP4F2CYP4A11 | |
| SCHEMBL387671 | 0.79 | GPR119 (0.73) | GPR119CYP4F2CYP4A11 | |
| SCHEMBL3985846 | 0.79 | GPR119 (0.54) | GPR119HDAC1CYP4F2CYP4A11 | |
| Trifluoroacetic Acid SCHEMBL387799 | 0.79 | GPR119 (0.57) | GPR119CYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120077812-A1 | BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS | FANG JING (US) | 2012-03-29 | — | — | US | disclosed |
| US-8101634-B2 | Bicyclic compounds and use as antidiabetics | GLAXOSMITHKLINE LLC (US) | 2012-01-24 | — | — | US | disclosed |
| US-20100029650-A1 | BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS | SMITH KLINE BEECHAM CORPORATION a corporation | 2010-02-04 | — | — | US | disclosed |
| EP-2094683-A2 | BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS | SmithKline Beecham Corporation (US) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008070692-A2 | BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-06-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077812-A1 | BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS | GPR119, GOT2, PC | GPR119 1/4885HDAC1 571/4885CYP4F2 329/4885 |
| US-20100029650-A1 | BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS | GPR119, GOT2, PC | GPR119 1/4885HDAC1 571/4885CYP4F2 329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.