Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 4/20 | 0.45 |
| ▸ | FEN1 | P39748 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.39 |
| ▸ | KDM6B | O15054 | 2/20 | 0.39 |
| ▸ | KDM4A | O75164 | 2/20 | 0.39 |
| ▸ | KDM5C | P41229 | 2/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.39 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL410537 | 0.91 | MEN1 (0.47) | ALOX5APFEN1MEN1KMT2AKDM4E | |
| SCHEMBL3885641 | 0.80 | MEN1 (0.43) | ALOX5APFEN1MEN1KMT2AGRM5 | |
| SCHEMBL27728541 | 0.77 | KDM4A (0.43) | ALOX5APFEN1MEN1KMT2ARAB9A | |
| SCHEMBL412186 | 0.77 | GRM5 (0.53) | MEN1KMT2AGRM5KDM4EALDH1A1 | |
| SCHEMBL3876005 | 0.77 | GRM5 (0.53) | MEN1KMT2AGRM5KDM4EALDH1A1 | |
| SCHEMBL27728460 | 0.77 | PDE2A (0.49) | MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL27707947 | 0.77 | ATM (0.51) | MEN1KMT2AGRM5KDM4EALDH1A1 | |
| SCHEMBL27670316 | 0.76 | GRM5 (0.41) | MEN1KMT2AGRM5MAPTRAB9A | |
| SCHEMBL27728466 | 0.75 | DRD2 (0.51) | KDM4EALDH1A1RAB9AKDM2AKDM6B | |
| SCHEMBL28774040 | 0.75 | KDM2B (0.41) | MEN1KMT2AGRM5KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2030970-A1 | Allosteric modulators of metabotropic glutamate receptors | ADDEX Pharma S.A. (CH) | 2009-03-04 | — | — | EP | claimed |
| EP-1685105-B1 | ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA SA (CH) | 2008-10-15 | — | — | EP | claimed |