Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.43 |
| ▸ | FEN1 | P39748 | 2/20 | 0.43 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 3/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.39 |
| ▸ | KDM6B | O15054 | 2/20 | 0.39 |
| ▸ | KDM4A | O75164 | 2/20 | 0.39 |
| ▸ | KDM5C | P41229 | 2/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.39 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL414961 | 0.90 | HSD11B1 (0.46) | MEN1KMT2APAK1BTKGRM5 | |
| SCHEMBL3875010 | 0.80 | ALOX5AP (0.45) | MEN1KMT2AALOX5APFEN1GRM5 | |
| SCHEMBL3887575 | 0.79 | NPC1 (0.42) | MEN1KMT2AGRM5POLB | |
| SCHEMBL408938 | 0.76 | GRM5 (0.54) | MEN1KMT2ABTKGRM5KDM4E | |
| SCHEMBL3887570 | 0.76 | GRM5 (0.54) | MEN1KMT2ABTKGRM5KDM4E | |
| SCHEMBL3877890 | 0.74 | ALOX5AP (0.45) | MEN1KMT2AALOX5APFEN1GRM5 | |
| SCHEMBL28761878 | 0.74 | BTK (0.44) | BTKGRM5POLBTSHR | |
| SCHEMBL3886420 | 0.74 | HPGDS (0.52) | MEN1KMT2AALOX5APFEN1 | |
| SCHEMBL3874494 | 0.74 | MEN1 (0.48) | MEN1KMT2AALOX5APFEN1GRM5 | |
| SCHEMBL3885085 | 0.74 | ALOX5AP (0.49) | MEN1KMT2AALOX5APFEN1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2030970-A1 | Allosteric modulators of metabotropic glutamate receptors | ADDEX Pharma S.A. (CH) | 2009-03-04 | — | — | EP | claimed |
| EP-1685105-B1 | ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA SA (CH) | 2008-10-15 | — | — | EP | claimed |