Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 2/20 | 0.52 |
| ▸ | PRKCA | P17252 | 5/20 | 0.51 |
| ▸ | AKT1 | P31749 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | GJB2 | P29033 | 1/20 | 0.47 |
| ▸ | LY96 | Q9Y6Y9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2198642 | 1.00 | TLR4 (0.52) | TLR4PRKCAAKT1MAPK1GJB2 | |
| SCHEMBL8144862 | 1.00 | TLR4 (0.52) | TLR4PRKCAAKT1MAPK1GJB2 | |
| SCHEMBL8145211 | 1.00 | TLR4 (0.52) | TLR4PRKCAAKT1MAPK1GJB2 | |
| SCHEMBL4856848 | 1.00 | TLR4 (0.52) | TLR4PRKCAAKT1MAPK1GJB2 | |
| SCHEMBL5425896 | 1.00 | TLR4 (0.52) | TLR4PRKCAAKT1MAPK1GJB2 | |
| SCHEMBL6290144 | 1.00 | TLR4 (0.52) | TLR4PRKCAAKT1MAPK1GJB2 | |
| SCHEMBL2198649 | 1.00 | TLR4 (0.52) | TLR4PRKCAAKT1MAPK1GJB2 | |
| SCHEMBL2297828 | 1.00 | TLR4 (0.52) | TLR4PRKCAAKT1MAPK1GJB2 | |
| SCHEMBL10325897 | 1.00 | TLR4 (0.52) | TLR4PRKCAAKT1MAPK1GJB2 | |
| SCHEMBL10326063 | 1.00 | TLR4 (0.52) | TLR4PRKCAAKT1MAPK1GJB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2575824-A2 | METHODS FOR THE TREATMENT AND PREVENTION OF INFLAMMATORY DISEASES | Children's Medical Center Corporation (US) | 2013-04-10 | — | — | EP | disclosed |
| WO-2011149881-A2 | METHODS FOR THE TREATMENT AND PREVENTION OF INFLAMMATORY DISEASES | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2011-12-01 | — | — | WO | disclosed |
| US-7491707-B1 | Synthetic lipid-a-analogs and uses thereof | BIOMIRA, INC. (CA) | 2009-02-17 | — | — | US | disclosed |
| CN-1029405-C | Lipid A analogs having immunoactivating and anti-tumor activity | SANKYO CO (JP) | 1995-08-02 | — | — | CN | disclosed |
| CN-1052481-A | Lipoid category-A with immunocompetence and anti-tumor activity is like thing | SANKYO CO (JP) | 1991-06-26 | — | — | CN | disclosed |