Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | NMT2 | O60551 | 2/20 | 0.46 |
| ▸ | NMT1 | P30419 | 2/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3926411 | 0.81 | OPRK1 (0.56) | ALDH1A1OPRK1DYRK1AMEN1KMT2A | |
| SCHEMBL21171822 | 0.78 | OPRK1 (0.57) | OPRK1MEN1KMT2AKDM4E | |
| SCHEMBL29501650 | 0.77 | KDM4E (0.49) | ALDH1A1NMT1L3MBTL1KMT2AKDM4E | |
| SCHEMBL25255731 | 0.77 | KDM4E (0.49) | ALDH1A1NMT1L3MBTL1KMT2AKDM4E | |
| SCHEMBL14598715 | 0.76 | ALDH1A1 (0.69) | ALDH1A1L3MBTL1MEN1KMT2AKDM4E | |
| SCHEMBL907923 | 0.74 | P2RY12 (0.49) | ALDH1A1 | |
| SCHEMBL3874439 | 0.73 | ALDH1A1 (0.76) | ALDH1A1L3MBTL1MEN1KMT2AKDM4E | |
| SCHEMBL30999840 | 0.73 | ALDH1A1 (0.76) | ALDH1A1L3MBTL1MEN1KMT2AKDM4E | |
| SCHEMBL2454645 | 0.73 | OPRK1 (0.57) | ALDH1A1OPRK1KMT2ALMNAADORA3 | |
| SCHEMBL10516498 | 0.73 | ALDH1A1 (0.51) | ALDH1A1NMT2NMT1L3MBTL1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041115-A1 | NEW PYRIDINE ANALOGUES | AstraZeneca AB (SE) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008004942-A1 | NEW PYRIDINE ANALOGUES | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | WO | disclosed |