Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 3/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.48 |
| ▸ | GALR2 | O43603 | 1/20 | 0.47 |
| ▸ | GALR1 | P47211 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3877744 | 0.91 | GALR2 (0.56) | TRPV1GALR2GALR1HRH4HSD11B1 | |
| SCHEMBL3876763 | 0.90 | GALR2 (0.57) | TRPV1GALR2GALR1HRH4HSD11B1 | |
| SCHEMBL3878613 | 0.90 | GALR2 (0.57) | TRPV1GALR2GALR1HRH4HSD11B1 | |
| SCHEMBL3876757 | 0.89 | MTOR (0.53) | MTORPIK3CATRPV1ATMNPSR1 | |
| SCHEMBL3878211 | 0.89 | NPSR1 (0.57) | MTORTRPV1ATMNPSR1TDP1 | |
| SCHEMBL3889718 | 0.89 | HSD11B1 (0.53) | MTORPIK3CATRPV1GALR2GALR1 | |
| SCHEMBL3882297 | 0.89 | NPSR1 (0.54) | MTORTRPV1ATMNPSR1TDP1 | |
| SCHEMBL3888789 | 0.88 | MTOR (0.49) | MTORPIK3CATRPV1GALR2GALR1 | |
| SCHEMBL3877647 | 0.88 | HSD11B1 (0.52) | MTORPIK3CATRPV1ATMNPSR1 | |
| SCHEMBL3878692 | 0.88 | TRPV1 (0.48) | PIK3CATRPV1GALR2GALR1HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | claimed |
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-20070027155-A1 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION | 2007-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027155-A1 | Biaryl piperazinyl-pyridine analogues | GPR174, GPR68, PPARG | MTOR 2949/4885PIK3CA 1107/4885TRPV1 244/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.