Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.41 |
| ▸ | GRM5 | P41594 | 6/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
| ▸ | PHGDH | O43175 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3891315 | 0.93 | MALT1 (0.41) | TRPV1HSD11B1MALT1 | |
| SCHEMBL3882315 | 0.88 | GALR2 (0.43) | GRM5HSD11B1 | |
| SCHEMBL3889310 | 0.86 | TRPV1 (0.41) | TRPV1GRM5HSD11B1L3MBTL1MALT1 | |
| SCHEMBL3880107 | 0.83 | HSD11B1 (0.43) | HSD11B1 | |
| SCHEMBL3878564 | 0.82 | GALR2 (0.44) | TRPV1GRM5HSD11B1L3MBTL1 | |
| SCHEMBL3880241 | 0.82 | MALT1 (0.43) | TRPV1HSD11B1MALT1 | |
| SCHEMBL3888979 | 0.81 | GALR2 (0.46) | TRPV1GRM5HSD11B1L3MBTL1 | |
| SCHEMBL3877289 | 0.80 | HSD11B1 (0.43) | HSD11B1 | |
| SCHEMBL3879062 | 0.80 | TRPV1 (0.43) | TRPV1GRM5MALT1 | |
| SCHEMBL3878640 | 0.80 | GALR2 (0.43) | GRM5HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |