Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 8/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3886728 | 0.91 | MALT1 (0.41) | MALT1TRPV1HSD11B1 | |
| SCHEMBL3881354 | 0.90 | TRPV1 (0.48) | TRPV1HSD11B1 | |
| SCHEMBL3891315 | 0.89 | MALT1 (0.41) | MALT1TRPV1HSD11B1 | |
| SCHEMBL3878113 | 0.89 | MALT1 (0.47) | MALT1TRPV1HSD11B1TRPA1 | |
| SCHEMBL3889310 | 0.83 | TRPV1 (0.41) | MALT1TRPV1HSD11B1 | |
| SCHEMBL3884876 | 0.83 | MALT1 (0.44) | MALT1TRPV1 | |
| SCHEMBL3887132 | 0.83 | MALT1 (0.45) | MALT1TRPV1 | |
| SCHEMBL3876785 | 0.82 | GALR2 (0.43) | MALT1TRPV1 | |
| SCHEMBL3878593 | 0.82 | TRPV1 (0.41) | MALT1TRPV1HSD11B1 | |
| SCHEMBL3878041 | 0.81 | MALT1 (0.44) | MALT1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-20070027155-A1 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION | 2007-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027155-A1 | Biaryl piperazinyl-pyridine analogues | GPR174, GPR68, PPARG | MALT1 1393/4885TRPV1 244/4885HSD11B1 3915/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.